N-(5-chloropyridine-2-yl)-2-{[4-methyl(methylcarbamoyl)-amino]-2-[3-(trifluoroacetyl-amino)propoxy]phenylcarbonyl}amino-5-methylbenzamide

Base Information

Chemical Name:N-(5-chloropyridine-2-yl)-2-{[4-methyl(methylcarbamoyl)-amino]-2-[3-(trifluoroacetyl-amino)propoxy]phenylcarbonyl}amino-5-methylbenzamide
CAS No.:1333127-42-6
Molecular Formula:C₂₈H₂₈ClF₃N₆O₅
Molecular Weight:621.016
Hs Code.:

Synonyms:N-(5-chloropyridine-2-yl)-2-{[4-methyl(methylcarbamoyl)-amino]-2-[3-(trifluoroacetyl-amino)propoxy]phenylcarbonyl}amino-5-methylbenzamide

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Chemical Property of N-(5-chloropyridine-2-yl)-2-{[4-methyl(methylcarbamoyl)-amino]-2-[3-(trifluoroacetyl-amino)propoxy]phenylcarbonyl}amino-5-methylbenzamide

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Technology Process of N-(5-chloropyridine-2-yl)-2-{[4-methyl(methylcarbamoyl)-amino]-2-[3-(trifluoroacetyl-amino)propoxy]phenylcarbonyl}amino-5-methylbenzamide

There total 5 articles about N-(5-chloropyridine-2-yl)-2-{[4-methyl(methylcarbamoyl)-amino]-2-[3-(trifluoroacetyl-amino)propoxy]phenylcarbonyl}amino-5-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333127-41-5
4-[methyl(methylcarbamoyl)amino]-2-[3-(trifluoroacetyl-amino)propoxy]benzoic acid

: 280773-05-9
N-(5-chloropyridin-2-yl)-2-amino-5-methylbenzamide

: 1333127-42-6
N-(5-chloropyridine-2-yl)-2-{[4-methyl(methylcarbamoyl)-amino]-2-[3-(trifluoroacetyl-amino)propoxy]phenylcarbonyl}amino-5-methylbenzamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; for 48h;

Reference yield:

: 1333127-49-3
4-[tertbutoxycarbonyl(methyl)amino]salicylic acid

: 1333127-42-6
N-(5-chloropyridine-2-yl)-2-{[4-methyl(methylcarbamoyl)-amino]-2-[3-(trifluoroacetyl-amino)propoxy]phenylcarbonyl}amino-5-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / 1 h / 110 °C

2: hydrogenchloride; water / ethanol / 3 h

3: tetrahydrofuran / 78 h

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 48 h

With hydrogenchloride; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol;

Reference yield:

: 1333127-39-1
2-[3-(trifluoroacetylamino)-propoxy]-4-[(tert-butoxycarbonyl)(methyl)amino]benzoic acid

: 1333127-42-6
N-(5-chloropyridine-2-yl)-2-{[4-methyl(methylcarbamoyl)-amino]-2-[3-(trifluoroacetyl-amino)propoxy]phenylcarbonyl}amino-5-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / ethanol / 3 h

2: tetrahydrofuran / 78 h

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 48 h

With hydrogenchloride; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol;