2'-O-(N-Fmoc)aminoethyl-5'-O-(4,4'-dimethoxytrityl)-4-N-Fmoc-5-methylcytidine

Base Information

• Chemical Name: 2'-O-(N-Fmoc)aminoethyl-5'-O-(4,4'-dimethoxytrityl)-4-N-Fmoc-5-methylcytidine
• CAS No.: 1363736-03-1
• Molecular Formula: C₆₃H₅₈N₄O₁₁
• Molecular Weight: 1047.17
• Mol file: 1363736-03-1.mol

Synonyms:2'-O-(N-Fmoc)aminoethyl-5'-O-(4,4'-dimethoxytrityl)-4-N-Fmoc-5-methylcytidine

Chemical Property of 2'-O-(N-Fmoc)aminoethyl-5'-O-(4,4'-dimethoxytrityl)-4-N-Fmoc-5-methylcytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-O-(N-Fmoc)aminoethyl-5'-O-(4,4'-dimethoxytrityl)-4-N-Fmoc-5-methylcytidine

There total 4 articles about 2'-O-(N-Fmoc)aminoethyl-5'-O-(4,4'-dimethoxytrityl)-4-N-Fmoc-5-methylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2'-O-(2-aminoethyl)-5'-O-(4,4'-dimethoxytrityl)-5-methylcytidine (1363736-01-9) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → 2'-O-(N-Fmoc)aminoethyl-5'-O-(4,4'-dimethoxytrityl)-4-N-Fmoc-5-methylcytidine (1363736-03-1)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1002/chem.201102287

Reference yield:

2'-O-(2-azidoethyl)-5'-O-(4,4'-dimethoxytrityl)-5-methylcytidine (1363735-99-2) → 2'-O-(N-Fmoc)aminoethyl-5'-O-(4,4'-dimethoxytrityl)-4-N-Fmoc-5-methylcytidine (1363736-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: water; triphenylphosphine / tetrahydrofuran / 12 h / 45 °C / Inert atmosphere

2: pyridine / dichloromethane / 16 h / 20 °C

With pyridine; water; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/chem.201102287

Reference yield:

C33H35N5O8 (1263796-39-9) → 2'-O-(N-Fmoc)aminoethyl-5'-O-(4,4'-dimethoxytrityl)-4-N-Fmoc-5-methylcytidine (1363736-03-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine / 14 h / 20 °C / Inert atmosphere

2.1: pyridine; 1,2,4-Triazole / 0.25 h / Inert atmosphere

2.2: 36 h / 0 - 20 °C / Inert atmosphere

2.3: 19 h / 20 °C / Inert atmosphere

3.1: water; triphenylphosphine / tetrahydrofuran / 12 h / 45 °C / Inert atmosphere

4.1: pyridine / dichloromethane / 16 h / 20 °C

With pyridine; 1,2,4-Triazole; water; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/chem.201102287

upstream raw materials:

C₃₃H₃₅N₅O₈

C₃₅H₃₇N₅O₉

2'-O-(2-azidoethyl)-5'-O-(4,4'-dimethoxytrityl)-5-methylcytidine

2'-O-(2-aminoethyl)-5'-O-(4,4'-dimethoxytrityl)-5-methylcytidine

Downstream raw materials:

2'-O-(N-Fmoc)aminoethyl-3'-O-[2-cyanoethyl(N,N-diisopropylamino)phosphanyl]-5'-O-(4,4'-dimethoxytrityl)-4-N-Fmoc-5-methylcytidine