(2S,4R,6R,8R,10S,11R)-8-benzyloxymethyl-11-iodo-10-(4-methoxy-benzyloxy)-2-[2-(4-methoxybenzyl)ethyl]-1,7-dioxa-spiro[5.5]undecan-4-ol

Base Information

Chemical Name:(2S,4R,6R,8R,10S,11R)-8-benzyloxymethyl-11-iodo-10-(4-methoxy-benzyloxy)-2-[2-(4-methoxybenzyl)ethyl]-1,7-dioxa-spiro[5.5]undecan-4-ol
CAS No.:475232-12-3
Molecular Formula:C₃₅H₄₃IO₈
Molecular Weight:718.626
Hs Code.:

Synonyms:(2S,4R,6R,8R,10S,11R)-8-benzyloxymethyl-11-iodo-10-(4-methoxy-benzyloxy)-2-[2-(4-methoxybenzyl)ethyl]-1,7-dioxa-spiro[5.5]undecan-4-ol

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Chemical Property of (2S,4R,6R,8R,10S,11R)-8-benzyloxymethyl-11-iodo-10-(4-methoxy-benzyloxy)-2-[2-(4-methoxybenzyl)ethyl]-1,7-dioxa-spiro[5.5]undecan-4-ol

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Technology Process of (2S,4R,6R,8R,10S,11R)-8-benzyloxymethyl-11-iodo-10-(4-methoxy-benzyloxy)-2-[2-(4-methoxybenzyl)ethyl]-1,7-dioxa-spiro[5.5]undecan-4-ol

There total 4 articles about (2S,4R,6R,8R,10S,11R)-8-benzyloxymethyl-11-iodo-10-(4-methoxy-benzyloxy)-2-[2-(4-methoxybenzyl)ethyl]-1,7-dioxa-spiro[5.5]undecan-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 475232-10-1
(2R,4S,4'S,6'R)-1-[6'-benzyloxymethyl-4'-(4-methoxy-benzyloxy)-5',6'-dihydro-4'H-pyran-2'-yl]-6-(4-methoxy-benzyloxy)-hexane-2,4-diol

: 475232-12-3
(2S,4R,6R,8R,10S,11R)-8-benzyloxymethyl-11-iodo-10-(4-methoxy-benzyloxy)-2-[2-(4-methoxybenzyl)ethyl]-1,7-dioxa-spiro[5.5]undecan-4-ol

Guidance literature:: With N-iodo-succinimide; In dichloromethane; acetonitrile; at -78 ℃; for 1h;
DOI:10.1021/ol026688x

Reference yield:

: 474745-86-3
(2S,4R,4'S,6'R)-1-[6'-benzyloxymethyl-4'-(4-methoxy-benzyloxy)-5',6'-dihydro-4'H-pyran-2'-yl]-6-(4-methoxy-benzyloxy)-hexane-2,4-diol

: 475232-12-3
(2S,4R,6R,8R,10S,11R)-8-benzyloxymethyl-11-iodo-10-(4-methoxy-benzyloxy)-2-[2-(4-methoxybenzyl)ethyl]-1,7-dioxa-spiro[5.5]undecan-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 139 mg / 18-crown-6 / toluene / 24 h / 80 °C

3: 88 percent / K₂CO₃ / methanol / 2 h / 23 °C

4: 84 percent / NIS / CH₂Cl₂; acetonitrile / 1 h / -78 °C

With N-iodo-succinimide; 18-crown-6 ether; potassium carbonate; triethylamine; In methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/ol026688x

Reference yield:

: 475232-11-2
(1R,3S,4'S,6'R) acetic acid 3-acetoxy-1-[6'-benzyloxymethyl-4'-(4-methoxy-benzyloxy)-5',6'-dihydro-4'H-pyran-2'-ylmethyl]-5-(4-methoxy-benzyloxy)-pentyl ester

: 475232-12-3
(2S,4R,6R,8R,10S,11R)-8-benzyloxymethyl-11-iodo-10-(4-methoxy-benzyloxy)-2-[2-(4-methoxybenzyl)ethyl]-1,7-dioxa-spiro[5.5]undecan-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / K₂CO₃ / methanol / 2 h / 23 °C

2: 84 percent / NIS / CH₂Cl₂; acetonitrile / 1 h / -78 °C

With N-iodo-succinimide; potassium carbonate; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/ol026688x