4-BROMO-2-(TRIFLUOROMETHOXY)ANISOLE

Base Information

• Chemical Name: 4-BROMO-2-(TRIFLUOROMETHOXY)ANISOLE
• CAS No.: 853771-88-7
• Molecular Formula: C8H6 Br F3 O2
• Molecular Weight: 271.034
• Hs Code.: 2909309090
• Mol file: 853771-88-7.mol

Synonyms:4-Bromo-1-methoxy-2-(trifluoromethoxy)benzene

Chemical Property of 4-BROMO-2-(TRIFLUOROMETHOXY)ANISOLE

Chemical Property:

• Vapor Pressure: 0.498mmHg at 25°C
• Refractive Index: 1.474
• Boiling Point: 198.806°C at 760 mmHg
• Flash Point: 92.687°C
• Density: 1.594g/cm³
• Storage Temp.: 2-8°C
• Water Solubility.: Insoluble in water.

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2-(trifluoromethoxy)anisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromo-2-(trifluoromethoxy)anisole employed in biological evaluation of some analogs of the antitumor agents.

Technology Process of 4-BROMO-2-(TRIFLUOROMETHOXY)ANISOLE

There total 2 articles about 4-BROMO-2-(TRIFLUOROMETHOXY)ANISOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.7%

4-bromo-2-(trifluoromethoxy)phenol (690264-39-2) + methyl iodide (74-88-4) → 4-bromo-1-methoxy-2-(trifluoromethoxy)benzene (853771-88-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

Reference yield:

2-(trifluoromethoxy)phenol (32858-93-8) → 4-bromo-1-methoxy-2-(trifluoromethoxy)benzene (853771-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / Br₂ / CH₂Cl₂ / 48 h / 20 °C

2: K₂CO₃ / acetone / 20 °C

With bromine; potassium carbonate; In dichloromethane; acetone;

DOI:10.1021/jm010579r

Reference yield: 60.0%

4-bromo-1-methoxy-2-(trifluoromethoxy)benzene (853771-88-7) + 4-methyl-N′-(1-(3,4,5-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide (1170045-84-7) → 1,2,3-trimethoxy-5-(1-(4-methoxy-3-(trifluoromethoxy)phenyl)vinyl)benzene

Guidance literature:

4-methyl-N′-(1-(3,4,5-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide; With dichloro bis(acetonitrile) palladium(II); In 1,4-dioxane; at 20 ℃; for 0.0333333h;

In 1,4-dioxane; for 0.0333333h; Alkaline conditions;

4-bromo-1-methoxy-2-(trifluoromethoxy)benzene; In 1,4-dioxane; at 100 ℃; for 3h; Sealed tube;

DOI:10.1016/j.ejmech.2017.11.055

upstream raw materials:

4-bromo-2-(trifluoromethoxy)phenol

methyl iodide

2-(trifluoromethoxy)phenol

Downstream raw materials:

4-methoxy-3-(trifluoromethoxy)-benzoic acid

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