(R)-N-(2-methylbenzyl)-3-[(2S,3S)-3-(2,6-dimethylphenoxyacetyl)amino-2-succinyloxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

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Chemical Name:(R)-N-(2-methylbenzyl)-3-[(2S,3S)-3-(2,6-dimethylphenoxyacetyl)amino-2-succinyloxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
CAS No.:364764-39-6
Molecular Formula:C₃₈H₄₅N₃O₈S
Molecular Weight:703.857
Hs Code.:

Synonyms:(R)-N-(2-methylbenzyl)-3-[(2S,3S)-3-(2,6-dimethylphenoxyacetyl)amino-2-succinyloxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

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Chemical Property of (R)-N-(2-methylbenzyl)-3-[(2S,3S)-3-(2,6-dimethylphenoxyacetyl)amino-2-succinyloxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

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Technology Process of (R)-N-(2-methylbenzyl)-3-[(2S,3S)-3-(2,6-dimethylphenoxyacetyl)amino-2-succinyloxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

There total 3 articles about (R)-N-(2-methylbenzyl)-3-[(2S,3S)-3-(2,6-dimethylphenoxyacetyl)amino-2-succinyloxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 108-30-5
succinic acid anhydride

: 365442-03-1
KNI-840

: 364764-39-6
(R)-N-(2-methylbenzyl)-3-[(2S,3S)-3-(2,6-dimethylphenoxyacetyl)amino-2-succinyloxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Guidance literature:: With N-cyclohexyl-cyclohexanamine; In tetrahydrofuran; diethyl ether; at 20 ℃;
DOI:10.1016/S0968-0896(01)00045-1

Reference yield:

: 13335-71-2
2-(2,6-dimethylphenoxy)acetic acid

: 364764-39-6
(R)-N-(2-methylbenzyl)-3-[(2S,3S)-3-(2,6-dimethylphenoxyacetyl)amino-2-succinyloxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 1-hydroxybenzotriazole; 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide*HCl / dimethylformamide / 18 h / 20 °C

2: 82 percent / dicyclohexylamine / tetrahydrofuran; diethyl ether / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-cyclohexyl-cyclohexanamine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00045-1

Reference yield:

: H-Apns-Dmt-NH(o-methylbenzyl) hydrochloride

: 364764-39-6
(R)-N-(2-methylbenzyl)-3-[(2S,3S)-3-(2,6-dimethylphenoxyacetyl)amino-2-succinyloxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 1-hydroxybenzotriazole; 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide*HCl / dimethylformamide / 18 h / 20 °C

2: 82 percent / dicyclohexylamine / tetrahydrofuran; diethyl ether / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-cyclohexyl-cyclohexanamine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00045-1