methyl 4'-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-4-fluorobiphenyl-2-carboxylate

Base Information

Chemical Name:methyl 4'-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-4-fluorobiphenyl-2-carboxylate
CAS No.:1415022-89-7
Molecular Formula:C₂₃H₂₄ClFN₂O₃
Molecular Weight:430.907
Hs Code.:

Synonyms:methyl 4'-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-4-fluorobiphenyl-2-carboxylate

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Chemical Property of methyl 4'-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-4-fluorobiphenyl-2-carboxylate

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Technology Process of methyl 4'-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-4-fluorobiphenyl-2-carboxylate

There total 4 articles about methyl 4'-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-4-fluorobiphenyl-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.6%

: 1415022-95-5
methyl 4'-((2-butyl-4-chloro-5-formyl-4,5-dihydro-1H-imidazol-1-yl)methyl)-4-fluorobiphenyl-2-carboxylate

: 1415022-89-7
methyl 4'-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-4-fluorobiphenyl-2-carboxylate

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.bmc.2012.09.065

Reference yield:

: 136834-55-4
C₁₅H₁₃FO₂

: 1415022-89-7
methyl 4'-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-4-fluorobiphenyl-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / cyclohexane / 3 h / Reflux

2: potassium carbonate / acetonitrile / 6 h / 50 °C / Inert atmosphere; Reflux

3: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In methanol; cyclohexane; acetonitrile;
DOI:10.1016/j.bmc.2012.09.065

Reference yield:

: 394-28-5
2-Bromo-5-fluorobenzoic acid

: 1415022-89-7
methyl 4'-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-4-fluorobiphenyl-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 4 h / Reflux

2: palladium diacetate; potassium carbonate; triphenylphosphine / 5 h / Inert atmosphere; Reflux

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / cyclohexane / 3 h / Reflux

4: potassium carbonate / acetonitrile / 6 h / 50 °C / Inert atmosphere; Reflux

5: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; palladium diacetate; potassium carbonate; triphenylphosphine; In methanol; cyclohexane; acetonitrile; 2: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.09.065