(3R)-1-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-(2,2-dimethyl-2-silapropyl)hex-5-en-3-ol

Base Information

Chemical Name:(3R)-1-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-(2,2-dimethyl-2-silapropyl)hex-5-en-3-ol
CAS No.:419541-53-0
Molecular Formula:C₂₆H₄₀O₂Si₂
Molecular Weight:440.773
Hs Code.:

Synonyms:(3R)-1-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-(2,2-dimethyl-2-silapropyl)hex-5-en-3-ol

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Chemical Property of (3R)-1-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-(2,2-dimethyl-2-silapropyl)hex-5-en-3-ol

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Technology Process of (3R)-1-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-(2,2-dimethyl-2-silapropyl)hex-5-en-3-ol

There total 5 articles about (3R)-1-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-(2,2-dimethyl-2-silapropyl)hex-5-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 63584-47-4
(1-tert-butylsulfanyl-vinyloxy)trimethylsilane

: 112897-03-7
3-(tert-butyldiphenylsilyloxy)-1-propanal

: 419541-53-0
(3R)-1-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-(2,2-dimethyl-2-silapropyl)hex-5-en-3-ol

Guidance literature:: With (R)-BITIP;
DOI:10.1021/ol050512o

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 419541-53-0
(3R)-1-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-(2,2-dimethyl-2-silapropyl)hex-5-en-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 5.0 g / imidazole / CH₂Cl₂ / 14 h

2: 92 percent / diisobutylaluminium hydride; potassium phthalate buffer solution / CH₂Cl₂; various solvent(s) / 3 h / pH 4.00

3: BINOL titanium tetraisopropoxide / CH₂Cl₂

With 1H-imidazole; potassium phthalate buffer solution; diisobutylaluminium hydride; titanium(IV) isopropylate; 1,1'-bi-2-naphthol; In dichloromethane;
DOI:10.1021/ol025645d

Reference yield:

: 129601-00-9
3-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)propionitrile

: 419541-53-0
(3R)-1-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-(2,2-dimethyl-2-silapropyl)hex-5-en-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / diisobutylaluminium hydride; potassium phthalate buffer solution / CH₂Cl₂; various solvent(s) / 3 h / pH 4.00

2: BINOL titanium tetraisopropoxide / CH₂Cl₂

With potassium phthalate buffer solution; diisobutylaluminium hydride; titanium(IV) isopropylate; 1,1'-bi-2-naphthol; In dichloromethane;
DOI:10.1021/ol025645d