129601-00-9

Upstream product

• 109-78-4 3-Hydroxypropionitrile 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 175838-16-1 3-((tert-butyldiphenylsilyl)oxy)-N'-hydroxypropanimidamide 
• 112897-03-7 3-(tert-butyldiphenylsilyloxy)-1-propanal 
• 883997-67-9 3-(tert-butyldiphenylsilyloxy)-propanamidine 
• 251455-87-5 5-[(S)-1-(tert-butyloxycarbonylamino)-2-phenylethyl]-3-[2-(tert-butyldiphenylsilyloxy)ethyl]-1,2,4-oxadiazole 
• 419541-63-2 1-(2-{(6R,2S)-4-methylene-6-[(phenylmethoxy)methyl](3,5,6-trihydro-2H-pyran-2-yl)}ethoxy)-2,2-dimethyl-1,1-diphenyl-1-silapropane 
• 419541-71-2 (3S)-1-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-(2,2-dimethyl-2-silapropil)hex-5-en-3-ol 
• 419541-53-0 (3R)-1-(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)-5-(2,2-dimethyl-2-silapropyl)hex-5-en-3-ol 

Relevant academic research and scientific papers

Pyran annulation: asymmetric synthesis of 2,6-disubstituted-4-methylene tetrahydropyrans.

[reaction: see text] A reaction process for the asymmetric construction of a variety of cis or trans disubstituted pyrans is described. This sequences allows for the asymmetric convergent union of two aldehydes with silyl-stannane reagent 1 in a two-step

COMPOUNDS AND USES THEREOF

The present invention relates to compositions and methods for the treatment of HA01 -associated disorders, such as primary hyperoxaluria 1.

TRIAZOLES AND THEIR USE AS BRADYKININ B1 RECEPTOR ANTAGONISTS

Compounds of Formula (I): are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

1,2,3,4-Tetrahydropyrazin-2-yl acetamides and methods of use

Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and

SUBSTITUTED SULFONAMIDOPROPIONAMIDES AND METHODS OF USE

This invention is in the field of pharmaceutical agents and specifically relates to compounds, compositions, uses and methods for treating inflammation-related disorders, including pain.

SUBSTITUTED SULFONES AND METHODS OF USE

Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Piperazine derivatives and methods of use

Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Design, synthesis, and evaluation of Phe-Gly mimetics: Heterocyclic building blocks for pseudopeptides

Enantiopure heterocyclic Boc-protected Phe-Gly dipeptidomimetics containing 1,3,4-oxadiazole, 1,2,4-oxadiazole, and 1,2,4-triazole ring systems have been synthesized as building blocks in the synthesis of pseudopeptides. Three derivatives (1-3) have the c