Cyclobutanecarboxylic acid, 1-(acetylamino)-2-methylene-, methyl ester

Base Information

Chemical Name:Cyclobutanecarboxylic acid, 1-(acetylamino)-2-methylene-, methyl ester
CAS No.:853305-15-4
Molecular Formula:C₉H₁₃NO₃
Molecular Weight:183.207
Hs Code.:
Mol file:853305-15-4.mol

Synonyms:Cyclobutanecarboxylic acid, 1-(acetylamino)-2-methylene-, methyl ester

Suppliers and Price of Cyclobutanecarboxylic acid, 1-(acetylamino)-2-methylene-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclobutanecarboxylic acid, 1-(acetylamino)-2-methylene-, methyl ester

Chemical Property:

PSA：55.40000
LogP:0.77520

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclobutanecarboxylic acid, 1-(acetylamino)-2-methylene-, methyl ester

There total 4 articles about Cyclobutanecarboxylic acid, 1-(acetylamino)-2-methylene-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 853305-14-3
1-acetamido-2-methylenecyclobutane-1-carboxylic acid

: 853305-15-4
methyl 1-acetamido-2-methylenecyclobutane-1-carboxylate

Guidance literature:: In diethyl ether; at 20 ℃; for 0.5h;
DOI:10.1016/j.tet.2005.02.039

Reference yield:

: 853305-12-1
N-[1-(tert-butyldiphenylsilyloxymethyl)-2-methylenecyclobutyl]acetamide

: 853305-15-4
methyl 1-acetamido-2-methylenecyclobutane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 25 °C

2: 64 percent / Jones reagent / acetone; H₂O / 4 h / 0 °C

3: 85 percent / diethyl ether / 0.5 h / 20 °C

With jones reagent; tetrabutyl ammonium fluoride; In tetrahydrofuran; diethyl ether; water; acetone;
DOI:10.1016/j.tet.2005.02.039

Reference yield:

: 832113-06-1
N-[1-(tert-butyldiphenylsilyloxymethyl)-2-oxocyclobutyl]acetamide

: 853305-15-4
methyl 1-acetamido-2-methylenecyclobutane-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 5 h / -78 - 25 °C

2: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 25 °C

3: 64 percent / Jones reagent / acetone; H₂O / 4 h / 0 °C

4: 85 percent / diethyl ether / 0.5 h / 20 °C

With jones reagent; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; In tetrahydrofuran; diethyl ether; water; acetone; toluene; 1: Wittig methylenation;
DOI:10.1016/j.tet.2005.02.039