N-[1-(tert-butyldiphenylsilyloxymethyl)-2-methylenecyclobutyl]acetamide

Base Information

Chemical Name:N-[1-(tert-butyldiphenylsilyloxymethyl)-2-methylenecyclobutyl]acetamide
CAS No.:853305-12-1
Molecular Formula:C₂₄H₃₁NO₂Si
Molecular Weight:393.601
Hs Code.:

Synonyms:N-[1-(tert-butyldiphenylsilyloxymethyl)-2-methylenecyclobutyl]acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[1-(tert-butyldiphenylsilyloxymethyl)-2-methylenecyclobutyl]acetamide

Chemical Property:

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Technology Process of N-[1-(tert-butyldiphenylsilyloxymethyl)-2-methylenecyclobutyl]acetamide

There total 1 articles about N-[1-(tert-butyldiphenylsilyloxymethyl)-2-methylenecyclobutyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 832113-06-1
N-[1-(tert-butyldiphenylsilyloxymethyl)-2-oxocyclobutyl]acetamide

: 853305-12-1
N-[1-(tert-butyldiphenylsilyloxymethyl)-2-methylenecyclobutyl]acetamide

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 - 25 ℃; for 5h;
DOI:10.1016/j.tet.2005.02.039

Reference yield: 89.0%

: 853305-12-1
N-[1-(tert-butyldiphenylsilyloxymethyl)-2-methylenecyclobutyl]acetamide

: (1RS,2SR)-N-[1-(tert-butyldiphenylsilyloxymethyl)-2-methylcyclobutyl]acetamide

: (1RS,2RS)-N-[1-(tert-butyldiphenylsilyloxymethyl)-2-methylcyclobutyl]acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1016/j.tet.2005.02.039

Reference yield:

: 853305-12-1
N-[1-(tert-butyldiphenylsilyloxymethyl)-2-methylenecyclobutyl]acetamide

: 853305-15-4
methyl 1-acetamido-2-methylenecyclobutane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 25 °C

2: 64 percent / Jones reagent / acetone; H₂O / 4 h / 0 °C

3: 85 percent / diethyl ether / 0.5 h / 20 °C

With jones reagent; tetrabutyl ammonium fluoride; In tetrahydrofuran; diethyl ether; water; acetone;
DOI:10.1016/j.tet.2005.02.039