Benzoic acid, 4-[1-[(4-Methylphenyl)sulfonyl]-5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-

Base Information

Chemical Name:Benzoic acid, 4-[1-[(4-Methylphenyl)sulfonyl]-5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-
CAS No.:1187209-20-6
Molecular Formula:C₂₇H₂₀N₂O₄S
Molecular Weight:468.533
Hs Code.:
Mol file:1187209-20-6.mol

Synonyms:4-(5-phenyl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid

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Chemical Property of Benzoic acid, 4-[1-[(4-Methylphenyl)sulfonyl]-5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-

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Technology Process of Benzoic acid, 4-[1-[(4-Methylphenyl)sulfonyl]-5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-

There total 5 articles about Benzoic acid, 4-[1-[(4-Methylphenyl)sulfonyl]-5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 890839-39-1
3-bromo-1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrolo[2,3-b]pyridine

: 14047-29-1
4-carboxyphenylboronic acid

: 1187209-20-6
4-(5-phenyl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; water; for 3h; Heating / reflux;

Reference yield:

: C₂₁H₁₅BrN₂O₄S

: 98-80-6
phenylboronic acid

: 1187209-20-6
4-(5-phenyl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 110 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.bmcl.2017.01.015

Reference yield:

: 14047-29-1
4-carboxyphenylboronic acid

: 1187209-20-6
4-(5-phenyl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 110 °C / Inert atmosphere

2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 110 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; 1: |Suzuki-Miyaura Coupling / 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2017.01.015