N-[(1S)-2,2,2-Trifluoro-1-{4-[({(2r)-2-[(5-fluoropyridin-2-yl)oxy]propyl}amino)methyl]phenyl}ethyl]-methanesulfonamide hydrochloride

Base Information

Chemical Name:N-[(1S)-2,2,2-Trifluoro-1-{4-[({(2r)-2-[(5-fluoropyridin-2-yl)oxy]propyl}amino)methyl]phenyl}ethyl]-methanesulfonamide hydrochloride
CAS No.:1448712-78-4
Molecular Formula:C₁₈H₂₁F₄N₃O₃S*ClH
Molecular Weight:471.904
Hs Code.:

Synonyms:N-[(1S)-2,2,2-Trifluoro-1-{4-[({(2r)-2-[(5-fluoropyridin-2-yl)oxy]propyl}amino)methyl]phenyl}ethyl]-methanesulfonamide hydrochloride

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Chemical Property of N-[(1S)-2,2,2-Trifluoro-1-{4-[({(2r)-2-[(5-fluoropyridin-2-yl)oxy]propyl}amino)methyl]phenyl}ethyl]-methanesulfonamide hydrochloride

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Technology Process of N-[(1S)-2,2,2-Trifluoro-1-{4-[({(2r)-2-[(5-fluoropyridin-2-yl)oxy]propyl}amino)methyl]phenyl}ethyl]-methanesulfonamide hydrochloride

There total 7 articles about N-[(1S)-2,2,2-Trifluoro-1-{4-[({(2r)-2-[(5-fluoropyridin-2-yl)oxy]propyl}amino)methyl]phenyl}ethyl]-methanesulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

: 34941-90-7
2,4-difluoropyridine

: 1448713-05-0
N-[(1S)-2,2,2-trifluoro-1-[4-[[[(2R)-2-hydroxypropyl]amino]methyl]phenyl]ethyl]methanesulfonamide

: 1448712-78-4
N-[(1S)-2,2,2-Trifluoro-1-{4-[({(2r)-2-[(5-fluoropyridin-2-yl)oxy]propyl}amino)methyl]phenyl}ethyl]-methanesulfonamide hydrochloride

Guidance literature:: N-[(1S)-2,2,2-trifluoro-1-[4-[[[(2R)-2-hydroxypropyl]amino]methyl]phenyl]ethyl]methanesulfonamide; With sodium hydride; In 1,4-dioxane; water; at 20 ℃; for 0.333333h; Inert atmosphere;

2,4-difluoropyridine; In 1,4-dioxane; water; at 105 ℃; for 18h;

With hydrogenchloride; In methanol; diethyl ether; at 20 ℃; for 0.0833333h;

Reference yield:

: 336105-31-8
N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]-(R)-2-methyl-propane-2-sulfinamide

: 1448712-78-4
N-[(1S)-2,2,2-Trifluoro-1-{4-[({(2r)-2-[(5-fluoropyridin-2-yl)oxy]propyl}amino)methyl]phenyl}ethyl]-methanesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / 1,3-dioxane; methanol / 1 h / 20 °C

2.1: dmap; 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C

3.1: palladium diacetate; hydrogen; catacxium A; N,N,N,N,-tetramethylethylenediamine / toluene / 16 h / 95 °C / 3878.71 Torr / Sealed tube

4.1: acetic acid / dichloromethane / 2 h / 20 °C

4.2: 20 °C

5.1: sodium hydride / water; 1,4-dioxane / 0.33 h / 20 °C / Inert atmosphere

5.2: 18 h / 105 °C

5.3: 0.08 h / 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; dmap; N,N,N,N,-tetramethylethylenediamine; hydrogen; palladium diacetate; sodium hydride; acetic acid; catacxium A; In 1,3-dioxane; 1,4-dioxane; methanol; dichloromethane; water; toluene;

Reference yield:

: 778565-93-8,843608-46-8,843608-53-7
(1S)-1-(4-bromophenyl)-2,2,2-trifluoroethanamine

: 1448712-78-4
N-[(1S)-2,2,2-Trifluoro-1-{4-[({(2r)-2-[(5-fluoropyridin-2-yl)oxy]propyl}amino)methyl]phenyl}ethyl]-methanesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C

2.1: palladium diacetate; hydrogen; catacxium A; N,N,N,N,-tetramethylethylenediamine / toluene / 16 h / 95 °C / 3878.71 Torr / Sealed tube

3.1: acetic acid / dichloromethane / 2 h / 20 °C

3.2: 20 °C

4.1: sodium hydride / water; 1,4-dioxane / 0.33 h / 20 °C / Inert atmosphere

4.2: 18 h / 105 °C

4.3: 0.08 h / 20 °C

With 2,6-dimethylpyridine; dmap; N,N,N,N,-tetramethylethylenediamine; hydrogen; palladium diacetate; sodium hydride; acetic acid; catacxium A; In 1,4-dioxane; dichloromethane; water; toluene;