N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]-(R)-2-methyl-propane-2-sulfinamide

Base Information

Chemical Name:N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]-(R)-2-methyl-propane-2-sulfinamide
CAS No.:336105-31-8
Molecular Formula:C₁₂H₁₅BrF₃NOS
Molecular Weight:358.222
Hs Code.:

Synonyms:N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]-(R)-2-methyl-propane-2-sulfinamide

Suppliers and Price of N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]-(R)-2-methyl-propane-2-sulfinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemicals and raw materials
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Total 4 raw suppliers

Chemical Property of N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]-(R)-2-methyl-propane-2-sulfinamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]-(R)-2-methyl-propane-2-sulfinamide

There total 4 articles about N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]-(R)-2-methyl-propane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1448681-98-8
(N-Z)-N-[(4-bromophenyl)methylene]-(R)-2-methyl-propane-2-sulfinamide

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 336105-31-8
N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]-(R)-2-methyl-propane-2-sulfinamide

Guidance literature:: With tetrabutylammonium acetate; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 1.5h;

Reference yield: 60.0%

: 16184-89-7
4'-bromo-2,2,2-trifluoroacetophenone

: 196929-78-9
(R)-2-methylpropane-2-sulfinamide

: 336105-31-8
N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]-(R)-2-methyl-propane-2-sulfinamide

Guidance literature:: 4'-bromo-2,2,2-trifluoroacetophenone; (R)-2-methylpropane-2-sulfinamide; With titanium(IV) isopropylate; In diethyl ether; for 24h; Reflux;

With L-Selectride; In diethyl ether; at -78 ℃; for 3h; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tet.2010.09.047

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 336105-31-8
N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]-(R)-2-methyl-propane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 0.25 h / 20 °C

1.2: 12 h / 20 °C

2.1: tetrabutylammonium acetate / N,N-dimethyl-formamide / 1.5 h / 0 - 5 °C

With tetrabutylammonium acetate; In N,N-dimethyl-formamide; toluene;