2-benzoyl-3-fluorobenzoic acid ethyl ester

Base Information

Chemical Name:2-benzoyl-3-fluorobenzoic acid ethyl ester
CAS No.:1131040-48-6
Molecular Formula:C₁₆H₁₃FO₃
Molecular Weight:272.276
Hs Code.:

Synonyms:2-benzoyl-3-fluorobenzoic acid ethyl ester

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Chemical Property of 2-benzoyl-3-fluorobenzoic acid ethyl ester

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Technology Process of 2-benzoyl-3-fluorobenzoic acid ethyl ester

There total 3 articles about 2-benzoyl-3-fluorobenzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: (2-(ethoxycarbonyl)-6-fluorophenyl)zinc pivalate

: 98-88-4
benzoyl chloride

: 1131040-48-6
2-benzoyl-3-fluorobenzoic acid ethyl ester

Guidance literature:: (2-(ethoxycarbonyl)-6-fluorophenyl)zinc pivalate; With chloro-trimethyl-silane; copper(I) cyanide di(lithium chloride); In tetrahydrofuran; at -45 - -20 ℃; for 0.5h; Inert atmosphere;

benzoyl chloride; In tetrahydrofuran; at -25 - 25 ℃; for 2h; Inert atmosphere;
DOI:10.1002/chem.201403015

Reference yield: 80.0%

: 451-02-5
ethyl 3-fluorobenzoate

: 98-88-4
benzoyl chloride

: 1131040-48-6
2-benzoyl-3-fluorobenzoic acid ethyl ester

Guidance literature:: ethyl 3-fluorobenzoate; With bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex; zinc(II) chloride; In tetrahydrofuran; at 25 ℃; for 3h; Inert atmosphere;

benzoyl chloride; With copper(l) cyanide; In tetrahydrofuran; at -40 - 25 ℃; Inert atmosphere;
DOI:10.1002/chem.200801558

Reference yield:

: 451-02-5
ethyl 3-fluorobenzoate

: 1131040-48-6
2-benzoyl-3-fluorobenzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere; Schlenk technique

1.2: 0.25 h / 0 - 25 °C / Inert atmosphere; Schlenk technique

2.1: copper(I) cyanide di(lithium chloride); chloro-trimethyl-silane / tetrahydrofuran / 0.5 h / -45 - -20 °C / Inert atmosphere

2.2: 2 h / -25 - 25 °C / Inert atmosphere

With chloro-trimethyl-silane; 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; copper(I) cyanide di(lithium chloride); In tetrahydrofuran; 2.1: |Negishi Coupling / 2.2: |Negishi Coupling;
DOI:10.1002/chem.201403015