2-(3,4-dimethoxyphenyl)-2-(phthalimidomethyl)-1,3-dioxolane

Base Information

• Chemical Name: 2-(3,4-dimethoxyphenyl)-2-(phthalimidomethyl)-1,3-dioxolane
• CAS No.: 109224-67-1
• Molecular Formula: C₂₀H₁₉NO₆
• Molecular Weight: 369.374
• Mol file: 109224-67-1.mol

Synonyms:2-(3,4-dimethoxyphenyl)-2-(phthalimidomethyl)-1,3-dioxolane

Chemical Property of 2-(3,4-dimethoxyphenyl)-2-(phthalimidomethyl)-1,3-dioxolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,4-dimethoxyphenyl)-2-(phthalimidomethyl)-1,3-dioxolane

There total 1 articles about 2-(3,4-dimethoxyphenyl)-2-(phthalimidomethyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Bromo-1-(3,4-dimethoxyphenyl)ethanone (1835-02-5) + potassium phtalimide (1074-82-4) + ethylene glycol (107-21-1) → 2-(3,4-dimethoxyphenyl)-2-(phthalimidomethyl)-1,3-dioxolane (109224-67-1)

Guidance literature:

With toluene-4-sulfonic acid; Yield given. Multistep reaction; 1)benzene, reflux until no more water distilled 2)HMPT, 180 deg C, 6h;

DOI:10.1002/jhet.5570230335

Reference yield: 95.0%

2-chloro-3-ethyl-4-quinazolinone (109192-35-0) + 2-(3,4-dimethoxyphenyl)-2-(phthalimidomethyl)-1,3-dioxolane (109224-67-1) → 1-(3,4-dimethoxyphenyl)-4-ethylimidazo<1,2-a>quinazolin-5-one (109224-68-2)

Guidance literature:

In N,N-dimethyl-formamide; for 0.75h; Heating;

DOI:10.1002/jhet.5570230335

Reference yield: 77.0%

2-(3,4-dimethoxyphenyl)-2-(phthalimidomethyl)-1,3-dioxolane (109224-67-1) → 2-(aminomethyl)-2-(3,4-dimethoxyphenyl)-1,2-dioxolane (109224-71-7)

Guidance literature:

With hydrazine hydrate; In ethanol; for 1h; Heating;

DOI:10.1002/jhet.5570230335

upstream raw materials:

2-Bromo-1-(3,4-dimethoxyphenyl)ethanone

potassium phtalimide

ethylene glycol

Downstream raw materials:

1-(3,4-dimethoxyphenyl)-4-ethylimidazo<1,2-a>quinazolin-5-one

2-(aminomethyl)-2-(3,4-dimethoxyphenyl)-1,2-dioxolane

1-(3,4-dihydroxyphenyl)-4-ethylimidazo<1,2-a>quinazolin-5-one