6-[{6-[{6-[{6-[tert-Butoxycarbonyl-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoic acid

Base Information

Chemical Name:6-[{6-[{6-[{6-[tert-Butoxycarbonyl-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoic acid
CAS No.:200713-67-3
Molecular Formula:C₆₁H₈₆N₄O₁₁
Molecular Weight:1051.37
Hs Code.:

6-[{6-[{6-[{6-[tert-Butoxycarbonyl-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoic acid

Synonyms:6-[{6-[{6-[{6-[tert-Butoxycarbonyl-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoic acid

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Chemical Property of 6-[{6-[{6-[{6-[tert-Butoxycarbonyl-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoic acid

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Technology Process of 6-[{6-[{6-[{6-[tert-Butoxycarbonyl-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoic acid

There total 11 articles about 6-[{6-[{6-[{6-[tert-Butoxycarbonyl-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 200713-65-1
6-[{6-[{6-[{6-[tert-Butoxycarbonyl-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoic acid ethyl ester

: 200713-67-3
6-[{6-[{6-[{6-[tert-Butoxycarbonyl-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoic acid

Guidance literature:: With sodium hydroxide; at 120 ℃;

Reference yield:

: 371-34-6
ethyl 6-aminohexanoate

: 200713-67-3
6-[{6-[{6-[{6-[tert-Butoxycarbonyl-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: p-CH₃-C₆H₄-SO₃H*H₂O / ethanol; toluene / 18 h / Heating

2: NaBH₄ / methanol / 40 - 50 °C

3: 71 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 98 percent / aq. NaOH / 120 °C

5: 75 percent / DCC, 1-HOBt / CH₂Cl₂ / 1.) r.t., 40 min, 2.) 5 deg C,18 h

6: 77 percent / TFA / CH₂Cl₂ / 5 h / Ambient temperature

7: 87 percent / DCC, 1-HOBt / CH₂Cl₂ / 1.) r.t., 1 h, 2.) r.t., 18 h

8: 93 percent / aq. NaOH / 120 °C

With sodium hydroxide; sodium tetrahydroborate; benzotriazol-1-ol; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol; ethanol; dichloromethane; toluene;

Reference yield:

: 6-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-hexanoic acid ethyl ester

: 200713-67-3
6-[{6-[{6-[{6-[tert-Butoxycarbonyl-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoyl}-(4-methoxy-benzyl)-amino]-hexanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: NaBH₄ / methanol / 40 - 50 °C

2: 71 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

3: 98 percent / aq. NaOH / 120 °C

4: 75 percent / DCC, 1-HOBt / CH₂Cl₂ / 1.) r.t., 40 min, 2.) 5 deg C,18 h

5: 77 percent / TFA / CH₂Cl₂ / 5 h / Ambient temperature

6: 87 percent / DCC, 1-HOBt / CH₂Cl₂ / 1.) r.t., 1 h, 2.) r.t., 18 h

7: 93 percent / aq. NaOH / 120 °C

With sodium hydroxide; sodium tetrahydroborate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol; dichloromethane;