(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-phenyl-propyl ester

Base Information

• Chemical Name: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-phenyl-propyl ester
• CAS No.: 66050-86-0
• Molecular Formula: C₁₉H₁₉F₃O₃
• Molecular Weight: 352.353

Synonyms:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-phenyl-propyl ester

Chemical Property of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-phenyl-propyl ester

Chemical Property:

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Technology Process of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-phenyl-propyl ester

There total 5 articles about (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-phenyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid (20445-31-2) + (S)-2-phenyl-1-propanol (37778-99-7) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-phenyl-propyl ester (66050-86-0)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1021/ja026620c

Reference yield:

(S)-2-phenyl-1-propanol (37778-99-7) + (S)-Mosher acid (17257-71-5,20445-31-2,56135-03-6,81655-41-6) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-phenyl-propyl ester (66050-86-0)

Guidance literature:

With dmap; 1,2-dichloro-ethane; In dichloromethane; at 20 ℃; for 20h; optical yield given as %ee;

DOI:10.1002/anie.200801928

Reference yield:

(RS)-2-phenyl-1-propanol (1123-85-9) + (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-2-phenyl-propyl ester (66050-85-9) + (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-phenyl-propyl ester (66050-86-0)

Guidance literature:

In pyridine; for 26h; Ambient temperature;

upstream raw materials:

(RS)-2-phenyl-1-propanol

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

(S)-2-phenyl-1-propanol

R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

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