cyclopropanecarboxylic acid (1-phenethyl-4-piperidinyl)phenylamide

Base Information

• Chemical Name: cyclopropanecarboxylic acid (1-phenethyl-4-piperidinyl)phenylamide
• CAS No.: 1169-68-2
• Molecular Formula: C₂₃H₂₈N₂O
• Molecular Weight: 348.488

Synonyms:cyclopropanecarboxylic acid (1-phenethyl-4-piperidinyl)phenylamide

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Chemical Property of cyclopropanecarboxylic acid (1-phenethyl-4-piperidinyl)phenylamide

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of cyclopropanecarboxylic acid (1-phenethyl-4-piperidinyl)phenylamide

There total 5 articles about cyclopropanecarboxylic acid (1-phenethyl-4-piperidinyl)phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

cyclopropanecarboxylic acid chloride (4023-34-1) + (1-Phenethyl-piperidin-4-yl)-phenyl-amine (21409-26-7) → cyclopropanecarboxylic acid (1-phenethyl-4-piperidinyl)phenylamide (1169-68-2)

Guidance literature:

With triethylamine; In toluene; at 23 - 24 ℃; for 0.5h;

DOI:10.3390/molecules24040740

Reference yield:

N-(1-phenethylpiperidin-4-ylidene)aniline (57958-48-2) → cyclopropanecarboxylic acid (1-phenethyl-4-piperidinyl)phenylamide (1169-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol

2: triethylamine / toluene / 0.5 h / 23 - 24 °C

With sodium tetrahydroborate; triethylamine; In methanol; toluene;

DOI:10.3390/molecules24040740

Reference yield:

1-(2-phenylethyl)-4-piperidinone (39742-60-4) → cyclopropanecarboxylic acid (1-phenethyl-4-piperidinyl)phenylamide (1169-68-2)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / toluene

2: sodium tetrahydroborate / methanol

3: triethylamine / toluene / 0.5 h / 23 - 24 °C

With sodium tetrahydroborate; acetic acid; triethylamine; In methanol; toluene;

DOI:10.3390/molecules24040740

upstream raw materials:

aniline

N-(1-phenethylpiperidin-4-ylidene)aniline

cyclopropanecarboxylic acid chloride

(1-Phenethyl-piperidin-4-yl)-phenyl-amine