(5R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D-prolinamide benzoate

Base Information

Chemical Name:(5R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D-prolinamide benzoate
CAS No.:1195787-64-4
Molecular Formula:C₇H₆O₂*C₃₁H₃₁F₇N₄O₂
Molecular Weight:746.725
Hs Code.:

(5R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D-prolinamide benzoate

Synonyms:(5R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D-prolinamide benzoate

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Chemical Property of (5R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D-prolinamide benzoate

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Technology Process of (5R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D-prolinamide benzoate

There total 9 articles about (5R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D-prolinamide benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1195787-56-4
(5R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D-prolinamide

: 65-85-0,8013-63-6
benzoic acid

: 1195787-64-4
(5R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D-prolinamide benzoate

Guidance literature:: In toluene; at 20 - 40 ℃;

Reference yield:

: 403519-98-2
(2R)-2-amino-2-methylpent-4-ynoic acid

: 1195787-64-4
(5R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D-prolinamide benzoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 17.5 h / 2 - 40 °C

2.1: potassium carbonate / 1,4-dioxane; water / 0.5 h / 20 °C

2.2: 17 h / 40 °C / Inert atmosphere

3.1: copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine / bis-triphenylphosphine-palladium(II) chloride / Reflux

3.2: Heating

4.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere; Reflux

4.2: 0.25 h

5.1: silver trifluoromethanesulfonate / dichloromethane; acetonitrile / 24 h / Reflux

6.1: ammonia / methanol / 120 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 20 °C

7.2: 0 °C

7.3: pH 12

8.1: toluene / 72 h / 20 - 40 °C

With copper(l) iodide; thionyl chloride; ammonia; silver trifluoromethanesulfonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1195787-93-9
methyl (R)-2-((tert-butoxycarbonyl)amino)-2-methylpent-4-ynoate

: 1195787-64-4
(5R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-methyl-D-prolinamide benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine / bis-triphenylphosphine-palladium(II) chloride / Reflux

1.2: Heating

2.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere; Reflux

2.2: 0.25 h

3.1: silver trifluoromethanesulfonate / dichloromethane; acetonitrile / 24 h / Reflux

4.1: ammonia / methanol / 120 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 20 °C

5.2: 0 °C

5.3: pH 12

6.1: toluene / 72 h / 20 - 40 °C

With copper(l) iodide; ammonia; silver trifluoromethanesulfonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In methanol; dichloromethane; toluene; acetonitrile;