(R)-methyl 2-(3-((R)-2-(3-((R)-2-(3-nitrophenoxy)propanamido)phenoxy)propanamido)phenoxy)propanoate

Base Information

Chemical Name:(R)-methyl 2-(3-((R)-2-(3-((R)-2-(3-nitrophenoxy)propanamido)phenoxy)propanamido)phenoxy)propanoate
CAS No.:1595156-75-4
Molecular Formula:C₂₈H₂₉N₃O₉
Molecular Weight:551.553
Hs Code.:

Synonyms:(R)-methyl 2-(3-((R)-2-(3-((R)-2-(3-nitrophenoxy)propanamido)phenoxy)propanamido)phenoxy)propanoate

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Chemical Property of (R)-methyl 2-(3-((R)-2-(3-((R)-2-(3-nitrophenoxy)propanamido)phenoxy)propanamido)phenoxy)propanoate

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Technology Process of (R)-methyl 2-(3-((R)-2-(3-((R)-2-(3-nitrophenoxy)propanamido)phenoxy)propanamido)phenoxy)propanoate

There total 6 articles about (R)-methyl 2-(3-((R)-2-(3-((R)-2-(3-nitrophenoxy)propanamido)phenoxy)propanamido)phenoxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1595156-73-2
(R)-methyl 2-(3-((R)-2-(3-aminophenoxy)propanamido)phenoxy)propanoate

: 77285-94-0
(R)-2-(3-nitrophenoxy)propanoic acid

: 1595156-75-4
(R)-methyl 2-(3-((R)-2-(3-((R)-2-(3-nitrophenoxy)propanamido)phenoxy)propanamido)phenoxy)propanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 - 20 ℃; for 26.5h;
DOI:10.1016/j.tetlet.2014.02.066

Reference yield:

: 554-84-7
meta-nitrophenol

: 1595156-75-4
(R)-methyl 2-(3-((R)-2-(3-((R)-2-(3-nitrophenoxy)propanamido)phenoxy)propanamido)phenoxy)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 28.5 h / 0 - 20 °C

2: lithium hydroxide / tetrahydrofuran; water / 7.5 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 26.5 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; water; 1: |Mitsunobu Displacement;
DOI:10.1016/j.tetlet.2014.02.066

Reference yield:

: 153546-07-7
methyl (R)-2-(3-nitrophenoxy)propionate

: 1595156-75-4
(R)-methyl 2-(3-((R)-2-(3-((R)-2-(3-nitrophenoxy)propanamido)phenoxy)propanamido)phenoxy)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran; water / 7.5 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 26.5 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; water;
DOI:10.1016/j.tetlet.2014.02.066