153546-07-7

Upstream product

• 17392-83-5 (R)-Methyl lactate 
• 554-84-7 meta-nitrophenol 
• 27871-49-4 (S)-Methyl lactate 
• 20047-41-0 methyl (2S)-2-bromopropanoate 
• 3118-78-3 potassium-3-nitrophenolate 

Downstream Products

• 1595156-81-2 (R)-2-(3-((R)-2-(3-((R)-2-(3-aminophenoxy)propanamido)phenoxy)propanamido)phenoxy)propanoic acid 
• 1595156-77-6 (R)-methyl 2-(3-((R)-2-(3-((R)-2-(3-aminophenoxy)propanamido)phenoxy)propanamido)phenoxy)propanoate 
• 1595156-75-4 (R)-methyl 2-(3-((R)-2-(3-((R)-2-(3-nitrophenoxy)propanamido)phenoxy)propanamido)phenoxy)propanoate 
• 1595156-73-2 (R)-methyl 2-(3-((R)-2-(3-aminophenoxy)propanamido)phenoxy)propanoate 
• 1595156-70-9 (R)-methyl 2-(3-((R)-2-(3-nitrophenoxy)propanamido)phenoxy)propanoate 
• 867219-48-5 methyl (R)-2-(3-aminophenoxy)propanoate 
• 77285-94-0 (R)-2-(3-nitrophenoxy)propanoic acid 

Relevant academic research and scientific papers

Asymmetric synthesis of photophore-containing lactisole derivatives to elucidate sweet taste receptors

Lactisole, which has a 2-phenoxy propionic acid skeleton, is well-known as an inhibitor of sweet taste receptors. We recently revealed some of the structure-activity relationships of the aromatic ring and chiral center of lactisole. Photoaffinity labeling

Binding of acetylcholine and quaternary ammonium compounds to a C 3-symmetric bowl-shaped tripeptide of 2-(3-aminophenoxy)propanoic acids acting as a ditopic receptor

The new tripeptide reported here is composed of (R)-2-(3-aminophenoxy) propionic acid and is a bowl-shaped receptor that simultaneously binds both cations and anions of acetylcholine chloride and benzyltrimethylammonium compounds. An intriguing conformati

PIPERIDINE DERIVATES FOR THE TREATMENT OF CHEMOKINES MEDIARED DISEASE

The present invention provides a compound of a formula (I) wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.

Optical resolution of aryloxypropionic acids and their esters by HPLC on cellulose tris-3,5-dimethyl-triphenylcarbamate derivative

Chiral chromatographic resolution of a series of antiphlogistic 2- aryloxypropionic acids and their methyl and ethyl esters was performed using a Chiralcel OD column. The CSP selected resolved most of the acids and esters efficiently, the enantiomers being well separated without requiring time consuming analysis. Chromatographic separation of R enriched samples was performed to determine the correct elution order. Using eluting systems such as hexane and 2-propanol, or hexane, 2-propanol and formic acid, the S enantiomer of all acids and esters was always found to elute first. We also considered the role of electron-donating or electron-withdrawing substituents (at the aryloxylic moiety) on the chiral resolution. It was shown that the electronic features of the substituents have more influence on the chiral interactions between the solutes and the CSP than their steric hindrance. Finally we determined, by molecular models, the interaction between CSP and solutes. In this way were able to determine all the potential sites for interactions, which are compatible with the conformations of the compounds and the structure of the stationary phase, and point out those interactions which enable chiral resolution.