tert-butyl (5-(((3S)-3-((4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)methyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Base Information

Chemical Name:tert-butyl (5-(((3S)-3-((4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)methyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate
CAS No.:1450620-58-2
Molecular Formula:C₃₀H₃₈F₆N₄O₇S
Molecular Weight:712.711
Hs Code.:

tert-butyl (5-(((3S)-3-((4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)methyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Synonyms:tert-butyl (5-(((3S)-3-((4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)methyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

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Chemical Property of tert-butyl (5-(((3S)-3-((4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)methyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

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Technology Process of tert-butyl (5-(((3S)-3-((4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)methyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

There total 11 articles about tert-butyl (5-(((3S)-3-((4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)methyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 278788-66-2
(R)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate

: 1450620-58-2
tert-butyl (5-(((3S)-3-((4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)methyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole; thionyl chloride / dichloromethane / 18 h / -78 - 20 °C

2.1: sodium periodate; ruthenium(III) trichloride hydrate / acetonitrile; ethyl acetate / 12 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 0.25 h / 20 °C

4.1: ruphos; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate / 1,4-dioxane / 1 h / 80 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 18 h

6.1: hydrogenchloride / 1,4-dioxane / 5 h

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

With 1H-imidazole; hydrogenchloride; sodium periodate; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; ruthenium(III) trichloride hydrate; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; ruphos; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 1450620-57-1
1,1,1,3,3,3-hexafluoro-2-(4-((2S)-2-((4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)methyl)-1-piperazinyl)phenyl)-2-propanol hydrochloride

: 1450620-16-2
tert-butyl (5-(chlorosulfonyl)-2-pyridinyl)carbamate

: 1450620-58-2
tert-butyl (5-(((3S)-3-((4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)methyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 18h;

Reference yield:

: 161117-88-0
(tert-butoxy)-N-(5-nitro(2-pyridyl))carboxamide

: 1450620-58-2
tert-butyl (5-(((3S)-3-((4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)methyl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium chloride; zinc / water; methanol; tetrahydrofuran / 12 h / 20 °C

2.1: sodium nitrite; hydrogenchloride / water; acetonitrile / 0.5 h / 0 °C

2.2: 0.75 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

With hydrogenchloride; ammonium chloride; N-ethyl-N,N-diisopropylamine; zinc; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;