(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 278788-66-2
• Molecular Formula: C10H20N2O3
• Molecular Weight: 216.28
• Hs Code.: 2933599090
• Mol file: 278788-66-2.mol

Synonyms:tert-Butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate;1,1-Dimethylethyl(R)-3-(hydroxymethyl)-1-piperazinecarboxylate;

Chemical Property of (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 2.15E-05mmHg at 25°C
• Refractive Index: 1.477
• Boiling Point: 322.9 °C at 760 mmHg
• PKA: 14.97±0.10(Predicted)
• Flash Point: 149.1 °C
• PSA: 61.80000
• Density: 1.085 g/cm³
• LogP: 0.45430
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% min ^*data from raw suppliers

(3R)-3-(Hydroxymethyl)piperazine, N1-Boc protected ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41-52
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R)-1-Boc-3-hydroxymethylpiperazine is a used as a building block for the preparation of PI3K inhibitors for rheumatoid arthritis treatment,benzoxaborole derivatives as antimalarial agents and anti-tuberculosis agents.

Technology Process of (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 1 articles about (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

N-Boc-piperazine-2-amidoanhydride (173774-50-0) → (R)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate (278788-66-2)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 48h; Heating / reflux;

Reference yield: 99.0%

(R)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate (278788-66-2) + benzyl chloroformate (501-53-1,94274-21-2) → O1-benzyl O4-(tert-butyl) (R)-2-(hydroxymethyl)piperazine-1,4-dicarboxylate (1217813-68-7,529516-61-8)

Guidance literature:

With sodium hydrogencarbonate; In water; ethyl acetate; at 0 - 10 ℃; for 5.5h;

Reference yield: 98.0%

(R)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate (278788-66-2) + tert-butyldimethylsilyl chloride (18162-48-6) → tert-butyl (3R)-3-[[tert-butyl(dimethyl)silyl]oxymethyl]piperazine-1-carboxylate

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

upstream raw materials:

N-Boc-piperazine-2-amidoanhydride

Downstream raw materials:

(R)-tert-butyl-3-(O-tert-butyldiphenylsilane)methyl-piperazine-1-carboxylate

(R)-tert-butyl 3-(hydroxymethyl)-4-methylpiperazine-1-carboxylate

1,1-dimethylethyl (3R)-4-[3-fluoro-5-(trifluoromethyl)-2-pyridinyl]-3-(hydroxymethyl)-1-piperazinecarboxylate

(R)-4-(2-chloroacetyl)-3-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester