N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine methyl ester

Base Information

• Chemical Name: N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine methyl ester
• CAS No.: 76203-92-4
• Molecular Formula: C₂₀H₂₅N₂O₆P
• Molecular Weight: 420.402
• Mol file: 76203-92-4.mol

Synonyms:N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine methyl ester

Chemical Property of N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine methyl ester

There total 3 articles about N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) + methyl N-(benzyloxycarbonyl)aminomethylphosphonochloridate (80556-22-5) → N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine methyl ester (76203-92-4)

Guidance literature:

With triethylamine; In chloroform; at 21 ℃; for 0.333333h; Yield given;

DOI:10.1021/ja00393a026

Reference yield:

dimethyl N-(benzyloxycarbonyl)aminomethylphosphonate (59191-35-4) → N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine methyl ester (76203-92-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / 2N NaOH, 2N H₂SO₄ / 0.75 h / 21 °C

2: SOCl₂ / CHCl₃ / 4 h / 21 °C

3: Et₃N / CHCl₃ / 0.33 h / 21 °C

With sodium hydroxide; thionyl chloride; sulfuric acid; triethylamine; In chloroform;

DOI:10.1021/ja00393a026

Reference yield:

methyl <(N-carbobenzoxyamino)methyl>phosphonic acid (76203-93-5) → N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine methyl ester (76203-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / CHCl₃ / 4 h / 21 °C

2: Et₃N / CHCl₃ / 0.33 h / 21 °C

With thionyl chloride; triethylamine; In chloroform;

DOI:10.1021/ja00393a026

upstream raw materials:

methyl (2S)-2-amino-3-phenylpropanoate

methyl N-(benzyloxycarbonyl)aminomethylphosphonochloridate

dimethyl N-(benzyloxycarbonyl)aminomethylphosphonate

methyl <(N-carbobenzoxyamino)methyl>phosphonic acid

Downstream raw materials:

N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine, dilithium salt