4-<<4-<(2-methyl-1-oxopropyl)amino>phenyl>oxoacetyl>-1-piperazineacetic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:4-<<4-<(2-methyl-1-oxopropyl)amino>phenyl>oxoacetyl>-1-piperazineacetic acid 1,1-dimethylethyl ester
CAS No.:219661-58-2
Molecular Formula:C₂₁H₂₉N₃O₅
Molecular Weight:403.478
Hs Code.:

Synonyms:4-<<4-<(2-methyl-1-oxopropyl)amino>phenyl>oxoacetyl>-1-piperazineacetic acid 1,1-dimethylethyl ester

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Chemical Property of 4-<<4-<(2-methyl-1-oxopropyl)amino>phenyl>oxoacetyl>-1-piperazineacetic acid 1,1-dimethylethyl ester

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Technology Process of 4-<<4-<(2-methyl-1-oxopropyl)amino>phenyl>oxoacetyl>-1-piperazineacetic acid 1,1-dimethylethyl ester

There total 3 articles about 4-<<4-<(2-methyl-1-oxopropyl)amino>phenyl>oxoacetyl>-1-piperazineacetic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 219661-56-0
4-<(2-methyl-1-oxopropyl)amino>-α-oxo-benzeneacetic acid

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 219661-58-2
4-<<4-<(2-methyl-1-oxopropyl)amino>phenyl>oxoacetyl>-1-piperazineacetic acid 1,1-dimethylethyl ester

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In chloroform; for 2h; Ambient temperature;
DOI:10.1021/ja982711r

Reference yield:

: 99-92-3
p-aminobenzophenone

: 219661-58-2
4-<<4-<(2-methyl-1-oxopropyl)amino>phenyl>oxoacetyl>-1-piperazineacetic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: 85 percent / SeO₂, pyridine / 14 h / 100 °C

3: 91 percent / N,N-diisopropylethylamine, bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CHCl₃ / 2 h / Ambient temperature

With pyridine; selenium(IV) oxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; chloroform;
DOI:10.1021/ja982711r

Reference yield:

: 128184-26-9
N-(4-acetylphenyl)-2-methyl-propanamide

: 219661-58-2
4-<<4-<(2-methyl-1-oxopropyl)amino>phenyl>oxoacetyl>-1-piperazineacetic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / SeO₂, pyridine / 14 h / 100 °C

2: 91 percent / N,N-diisopropylethylamine, bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CHCl₃ / 2 h / Ambient temperature

With pyridine; selenium(IV) oxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In chloroform;
DOI:10.1021/ja982711r