Iso Furosemide

Base Information

• Chemical Name: Iso Furosemide
• CAS No.: 4818-59-1
• Molecular Formula: C12H11 Cl N2 O5 S
• Molecular Weight: 330.74
• Mol file: 4818-59-1.mol

Synonyms:Benzoicacid, 2-chloro-4-(furfurylamino)-5-sulfamoyl- (7CI,8CI); H 20; Isofurosemide;Isolasix

Chemical Property of Iso Furosemide

Chemical Property:

• Melting Point: 201-202℃ (decomposition)
• Boiling Point: 578.4±60.0 °C(Predicted)
• PKA: 2.99±0.25(Predicted)
• Density: 1.606±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

IsoFurosemide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Iso Furosemide (Furosemide EP Impurity A) is a Furosemide (F865000) derivative which enhanced urinary excretion of active kallikrein. A Furosemide (F865000) derivative which enhanced urinary excretion of active kallikrein

Technology Process of Iso Furosemide

There total 2 articles about Iso Furosemide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

furan-2-ylmethanamine (617-89-0) + 2-chloro-4-fluoro-5-sulfamoylbenzoic acid (4793-24-2) → 2-chloro-4-furfurylamino-5-sulfamoyl-benzoic acid (4818-59-1)

Guidance literature:

furan-2-ylmethanamine; 2-chloro-4-fluoro-5-sulfamoylbenzoic acid; at 100 ℃; for 3h;

With hydrogenchloride; In water; toluene; for 0.0833333h;

Reference yield:

→ 2-chloro-4-furfurylamino-5-sulfamoyl-benzoic acid (4818-59-1)

Guidance literature:

Δ, 4-Fluor-2-chlor-5-sulfamoyl-benzoesaeure, Furfurylamin, auf dem W.-Bad (2h);

Reference yield: 64.3%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-chloro-4-furfurylamino-5-sulfamoyl-benzoic acid (4818-59-1) → 2-Chlor-4--5-sulfamoyl-benzoesaeure-methylester (4818-66-0)

Guidance literature:

for 0.5h;

upstream raw materials:

furan-2-ylmethanamine

2-chloro-4-fluoro-5-sulfamoylbenzoic acid

Downstream raw materials:

2,4-bis-furfurylamino-5-sulfamoyl-benzoic acid

2-Chlor-4--5-sulfamoyl-benzoesaeure-methylester

Refernces