5-{4-[(2-fluoro-2-{3-[(1-methylethyl)oxy]phenyl}ethyl)oxy]phenyl}-3-{[(methyloxy)methyl]oxy}isoxazole

Base Information

Chemical Name:5-{4-[(2-fluoro-2-{3-[(1-methylethyl)oxy]phenyl}ethyl)oxy]phenyl}-3-{[(methyloxy)methyl]oxy}isoxazole
CAS No.:1198745-12-8
Molecular Formula:C₂₂H₂₄FNO₅
Molecular Weight:401.435
Hs Code.:

Synonyms:5-{4-[(2-fluoro-2-{3-[(1-methylethyl)oxy]phenyl}ethyl)oxy]phenyl}-3-{[(methyloxy)methyl]oxy}isoxazole

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Chemical Property of 5-{4-[(2-fluoro-2-{3-[(1-methylethyl)oxy]phenyl}ethyl)oxy]phenyl}-3-{[(methyloxy)methyl]oxy}isoxazole

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Technology Process of 5-{4-[(2-fluoro-2-{3-[(1-methylethyl)oxy]phenyl}ethyl)oxy]phenyl}-3-{[(methyloxy)methyl]oxy}isoxazole

There total 10 articles about 5-{4-[(2-fluoro-2-{3-[(1-methylethyl)oxy]phenyl}ethyl)oxy]phenyl}-3-{[(methyloxy)methyl]oxy}isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1198745-11-7
1-{3-[(1-methylethyl)oxy]phenyl}-2-{[4-(3-{[(methyloxy)methyl]oxy}isoxazol-5-yl)phenyl]oxy}ethanol

: 1198745-12-8
5-{4-[(2-fluoro-2-{3-[(1-methylethyl)oxy]phenyl}ethyl)oxy]phenyl}-3-{[(methyloxy)methyl]oxy}isoxazole

Guidance literature:: With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at 0 ℃; for 0.5h; Cooling with ice;

Reference yield:

: 1030828-97-7
5-[4-(benzyloxy)phenyl]-3-(methoxymethoxy)-1,2-oxazole

: 1198745-12-8
5-{4-[(2-fluoro-2-{3-[(1-methylethyl)oxy]phenyl}ethyl)oxy]phenyl}-3-{[(methyloxy)methyl]oxy}isoxazole

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.5 h / 0 °C / Cooling with ice

4: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 0.5 h / 0 °C / Cooling with ice

With methanol; sodium tetrahydroborate; hydrogen; potassium carbonate; (bis-(2-methoxyethyl)amino)sulfur trufluoride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1030828-96-6
5-[4-(benzyloxy)phenyl]-1,2-oxazol-3-ol

: 1198745-12-8
5-{4-[(2-fluoro-2-{3-[(1-methylethyl)oxy]phenyl}ethyl)oxy]phenyl}-3-{[(methyloxy)methyl]oxy}isoxazole

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 20 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.5 h / 0 °C / Cooling with ice

5: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 0.5 h / 0 °C / Cooling with ice

With methanol; sodium tetrahydroborate; hydrogen; potassium carbonate; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;