2-(methylthio)ethyl 8-acetyl-α-(1-acetyl-6-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-5-(1,2-dioxopropyl)-5,6,7,8-tetrahydro-2,4-bis(phenylmethoxy)-6-pteridineacetate

Base Information

Chemical Name:2-(methylthio)ethyl 8-acetyl-α-(1-acetyl-6-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-5-(1,2-dioxopropyl)-5,6,7,8-tetrahydro-2,4-bis(phenylmethoxy)-6-pteridineacetate
CAS No.:94779-80-3
Molecular Formula:C₄₀H₃₆BrN₅O₉S
Molecular Weight:842.724
Hs Code.:

2-(methylthio)ethyl 8-acetyl-α-(1-acetyl-6-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-5-(1,2-dioxopropyl)-5,6,7,8-tetrahydro-2,4-bis(phenylmethoxy)-6-pteridineacetate

Synonyms:2-(methylthio)ethyl 8-acetyl-α-(1-acetyl-6-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-5-(1,2-dioxopropyl)-5,6,7,8-tetrahydro-2,4-bis(phenylmethoxy)-6-pteridineacetate

Suppliers and Price of 2-(methylthio)ethyl 8-acetyl-α-(1-acetyl-6-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-5-(1,2-dioxopropyl)-5,6,7,8-tetrahydro-2,4-bis(phenylmethoxy)-6-pteridineacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(methylthio)ethyl 8-acetyl-α-(1-acetyl-6-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-5-(1,2-dioxopropyl)-5,6,7,8-tetrahydro-2,4-bis(phenylmethoxy)-6-pteridineacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(methylthio)ethyl 8-acetyl-α-(1-acetyl-6-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-5-(1,2-dioxopropyl)-5,6,7,8-tetrahydro-2,4-bis(phenylmethoxy)-6-pteridineacetate

There total 15 articles about 2-(methylthio)ethyl 8-acetyl-α-(1-acetyl-6-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-5-(1,2-dioxopropyl)-5,6,7,8-tetrahydro-2,4-bis(phenylmethoxy)-6-pteridineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 94779-78-9
2-(methylthio)ethyl 8-acetyl-α-(1-acetyl-6-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-5,6,7,8-tetrahydro-2,4-bis(phenylmethoxy)-6-pteridineacetate

: 5704-66-5
pyruvoyl chloride

: 94779-80-3
2-(methylthio)ethyl 8-acetyl-α-(1-acetyl-6-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-5-(1,2-dioxopropyl)-5,6,7,8-tetrahydro-2,4-bis(phenylmethoxy)-6-pteridineacetate

Guidance literature:: In benzene; for 5h; Ambient temperature;
DOI:10.1016/S0040-4020(01)86989-1

Reference yield:

: 6326-79-0
6-bromoisatin

: 94779-80-3
2-(methylthio)ethyl 8-acetyl-α-(1-acetyl-6-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-5-(1,2-dioxopropyl)-5,6,7,8-tetrahydro-2,4-bis(phenylmethoxy)-6-pteridineacetate

Guidance literature:: Multi-step reaction with 8 steps

1: 82 percent / piperidine, acetic acid / benzene / 5 h / Heating

2: 92 percent / Na₂S₂O₄ / ethanol; H₂O / 0.08 h / Heating

3: 27 percent / NH₂NH₂*H₂O / CH₂Cl₂; methanol / 0.5 h

4: 90 percent / NaHCO₃ / dimethylformamide / 1 h / Ambient temperature

5: 94 percent / Zn, AcOH / tetrahydrofuran / 10 h / 0 °C

6: 50 percent / pyridine / 2 h / 70 °C

7: 68 percent / NaBH₃CN, 2N aq. HCl / ethyl acetate / 0.17 h

8: 92 percent / benzene / 5 h / Ambient temperature

With piperidine; pyridine; hydrogenchloride; sodium dithionite; sodium cyanoborohydride; sodium hydrogencarbonate; hydrazine hydrate; acetic acid; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)86989-1

Reference yield:

: 94779-72-3
2-(methylthio)ethyl 6-bromo-α-<(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl>-2,3-dihydro-2-oxo-1H-indole-3-acetate

: 94779-80-3
2-(methylthio)ethyl 8-acetyl-α-(1-acetyl-6-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-5-(1,2-dioxopropyl)-5,6,7,8-tetrahydro-2,4-bis(phenylmethoxy)-6-pteridineacetate

Guidance literature:: Multi-step reaction with 6 steps

1: 27 percent / NH₂NH₂*H₂O / CH₂Cl₂; methanol / 0.5 h

2: 90 percent / NaHCO₃ / dimethylformamide / 1 h / Ambient temperature

3: 94 percent / Zn, AcOH / tetrahydrofuran / 10 h / 0 °C

4: 50 percent / pyridine / 2 h / 70 °C

5: 68 percent / NaBH₃CN, 2N aq. HCl / ethyl acetate / 0.17 h

6: 92 percent / benzene / 5 h / Ambient temperature

With pyridine; hydrogenchloride; sodium cyanoborohydride; sodium hydrogencarbonate; hydrazine hydrate; acetic acid; zinc; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)86989-1