tert-butyl (7-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)((4-fluoro-3-nitrophenyl)sulfonyl)carbamate

Base Information

Chemical Name:tert-butyl (7-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)((4-fluoro-3-nitrophenyl)sulfonyl)carbamate
CAS No.:1421687-51-5
Molecular Formula:C₃₃H₃₂ClFN₈O₆S
Molecular Weight:723.184
Hs Code.:

Synonyms:tert-butyl (7-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)((4-fluoro-3-nitrophenyl)sulfonyl)carbamate

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Chemical Property of tert-butyl (7-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)((4-fluoro-3-nitrophenyl)sulfonyl)carbamate

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Technology Process of tert-butyl (7-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)((4-fluoro-3-nitrophenyl)sulfonyl)carbamate

There total 7 articles about tert-butyl (7-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)((4-fluoro-3-nitrophenyl)sulfonyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 6668-56-0
4-fluoro-3-nitrobenzene-1-sulfonyl chloride

: 1421687-41-3
tert-butyl (7-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)carbamate

: 1421687-51-5
tert-butyl (7-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)((4-fluoro-3-nitrophenyl)sulfonyl)carbamate

Guidance literature:: tert-butyl (7-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)carbamate; With sodium hydride; In tetrahydrofuran; mineral oil; at -78 - 0 ℃; for 0.25h; Inert atmosphere;

4-fluoro-3-nitrobenzene-1-sulfonyl chloride; In tetrahydrofuran; mineral oil; at -78 - 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ml300321d

Reference yield:

: 1274804-87-3
4’-chloro-2-iodomethyl-biphenyl

: 1421687-51-5
tert-butyl (7-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)((4-fluoro-3-nitrophenyl)sulfonyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile; N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

2.1: trichlorophosphate; pyridine / 2 h / 110 °C / Inert atmosphere

3.1: pyridine; hydrazine / 0.5 h / 180 °C / Inert atmosphere; Sealed tube

4.1: tetrahydrofuran / 12 h / 40 °C / Inert atmosphere

5.1: dmap / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / -78 - 0 °C / Inert atmosphere

6.2: 0.5 h / -78 - 0 °C / Inert atmosphere

With pyridine; dmap; sodium hydride; N-ethyl-N,N-diisopropylamine; hydrazine; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/ml300321d

Reference yield:

: 1421687-37-7
5-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)pyridazin-3(2H)-one

: 1421687-51-5
tert-butyl (7-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)((4-fluoro-3-nitrophenyl)sulfonyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate; pyridine / 2 h / 110 °C / Inert atmosphere

2.1: pyridine; hydrazine / 0.5 h / 180 °C / Inert atmosphere; Sealed tube

3.1: tetrahydrofuran / 12 h / 40 °C / Inert atmosphere

4.1: dmap / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / -78 - 0 °C / Inert atmosphere

5.2: 0.5 h / -78 - 0 °C / Inert atmosphere

With pyridine; dmap; sodium hydride; hydrazine; trichlorophosphate; In tetrahydrofuran; mineral oil;
DOI:10.1021/ml300321d