3(2H)-Pyridazinone,5-(1-piperazinyl)-(9CI)

Base Information

• Chemical Name: 3(2H)-Pyridazinone,5-(1-piperazinyl)-(9CI)
• CAS No.: 159430-52-1
• Molecular Formula: C8H12 N4 O
• Molecular Weight: 180.21
• Mol file: 159430-52-1.mol

Synonyms:3(2H)-Pyridazinone,5-(1-piperazinyl)-(9CI);5-PIPERAZIN-1-YLPYRIDAZIN-3(2H)-ONE

Chemical Property of 3(2H)-Pyridazinone,5-(1-piperazinyl)-(9CI)

Chemical Property:

• PKA: 11.22±0.40(Predicted)
• PSA: 61.28000
• Density: 1.42±0.1 g/cm3(Predicted)
• LogP: -0.01440

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3(2H)-Pyridazinone,5-(1-piperazinyl)-(9CI)

There total 2 articles about 3(2H)-Pyridazinone,5-(1-piperazinyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-chloro-5-piperazin-1-yl-pyridazin-3-one hydrochloride → 5-(1-piperazinyl)-3(2H)-pyridazinone (159430-52-1)

Guidance literature:

With palladium 10% on activated carbon; hydrazine hydrate; In ethanol; at 50 ℃; for 1h;

DOI:10.1021/jm800962k

Reference yield: 40.0%

4-chloro-5-(piperazin-1-yl)-2,3-dihydropyridazin-3-one (153276-34-7) → 5-(1-piperazinyl)-3(2H)-pyridazinone (159430-52-1)

Guidance literature:

With potassium hydroxide; hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;

DOI:10.1002/ardp.19943271006

Reference yield: 60.0%

4’-chloro-2-iodomethyl-biphenyl (1274804-87-3) + 5-(1-piperazinyl)-3(2H)-pyridazinone (159430-52-1) → 5-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)pyridazin-3(2H)-one (1421687-37-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/ml300321d

upstream raw materials:

4-chloro-5-(piperazin-1-yl)-2,3-dihydropyridazin-3-one

Downstream raw materials:

3-chloro-5-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)pyridazine

5-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-3-hydrazinylpyridazine

7-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-amine

tert-butyl (7-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)carbamate

Refernces

• 1、 Corsano,Scapicchi,Strappaghetti. "Bronchodilator activity of theophylline derivatives substituted at the 7-position". . p. 631 - 635. Retrieved 2007/10/02.