N-(3,5-difluorobenzyl)-N-(5-chlorothiophene-2-sulfonyl)-D-leucinamide

Base Information

Chemical Name:N-(3,5-difluorobenzyl)-N-(5-chlorothiophene-2-sulfonyl)-D-leucinamide
CAS No.:1609199-99-6
Molecular Formula:C₁₇H₁₉ClF₂N₂O₃S₂
Molecular Weight:436.931
Hs Code.:

Synonyms:N-(3,5-difluorobenzyl)-N-(5-chlorothiophene-2-sulfonyl)-D-leucinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3,5-difluorobenzyl)-N-(5-chlorothiophene-2-sulfonyl)-D-leucinamide

Chemical Property:

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Technology Process of N-(3,5-difluorobenzyl)-N-(5-chlorothiophene-2-sulfonyl)-D-leucinamide

There total 2 articles about N-(3,5-difluorobenzyl)-N-(5-chlorothiophene-2-sulfonyl)-D-leucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1609199-87-2
N-(5-chlorothiophene-2-sulfonyl)-D-leucinamide

: 141776-91-2
1-bromomethyl-3,5-difluoro-benzene

: 1609199-99-6
N-(3,5-difluorobenzyl)-N-(5-chlorothiophene-2-sulfonyl)-D-leucinamide

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1016/j.ejmech.2014.04.006

Reference yield:

: 80970-09-8
(R)-2-amino-4-methylpentanamide hydrochloride

: 1609199-99-6
N-(3,5-difluorobenzyl)-N-(5-chlorothiophene-2-sulfonyl)-D-leucinamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 48 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.04.006