methyl (1R,15S,17R,18R,19S,20S)-6-{[(tert-butoxy)carbonyl]oxy}-17-({4-[(ethoxycarbonyl)oxy]-3,5-dimethoxyphenyl}carbonyloxy)-18-methoxy-3,13-diazapentacyclo[11.8.0.0^2,10.0^4,9.0^15,20]henicosa-2⁽¹⁰⁾,4,6,8-tetraene-19-carboxylate

Base Information

• Chemical Name: methyl (1R,15S,17R,18R,19S,20S)-6-{[(tert-butoxy)carbonyl]oxy}-17-({4-[(ethoxycarbonyl)oxy]-3,5-dimethoxyphenyl}carbonyloxy)-18-methoxy-3,13-diazapentacyclo[11.8.0.0^2,10.0^4,9.0^15,20]henicosa-2⁽¹⁰⁾,4,6,8-tetraene-19-carboxylate
• CAS No.: 1535202-89-1
• Molecular Formula: C₃₉H₄₈N₂O₁₃
• Molecular Weight: 752.816

Synonyms:methyl (1R,15S,17R,18R,19S,20S)-6-{[(tert-butoxy)carbonyl]oxy}-17-({4-[(ethoxycarbonyl)oxy]-3,5-dimethoxyphenyl}carbonyloxy)-18-methoxy-3,13-diazapentacyclo[11.8.0.0^2,10.0^4,9.0^15,20]henicosa-2⁽¹⁰⁾,4,6,8-tetraene-19-carboxylate

Chemical Property of methyl (1R,15S,17R,18R,19S,20S)-6-{[(tert-butoxy)carbonyl]oxy}-17-({4-[(ethoxycarbonyl)oxy]-3,5-dimethoxyphenyl}carbonyloxy)-18-methoxy-3,13-diazapentacyclo[11.8.0.0^2,10.0^4,9.0^15,20]henicosa-2⁽¹⁰⁾,4,6,8-tetraene-19-carboxylate

Chemical Property:

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Technology Process of methyl (1R,15S,17R,18R,19S,20S)-6-{[(tert-butoxy)carbonyl]oxy}-17-({4-[(ethoxycarbonyl)oxy]-3,5-dimethoxyphenyl}carbonyloxy)-18-methoxy-3,13-diazapentacyclo[11.8.0.0^2,10.0^4,9.0^15,20]henicosa-2⁽¹⁰⁾,4,6,8-tetraene-19-carboxylate

There total 4 articles about methyl (1R,15S,17R,18R,19S,20S)-6-{[(tert-butoxy)carbonyl]oxy}-17-({4-[(ethoxycarbonyl)oxy]-3,5-dimethoxyphenyl}carbonyloxy)-18-methoxy-3,13-diazapentacyclo[11.8.0.0^2,10.0^4,9.0^15,20]henicosa-2⁽¹⁰⁾,4,6,8-tetraene-19-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(ethoxycarbonyl)oxy]-3,5-dimethoxybenzoic acid (18780-67-1) + methyl (1R,15S,17R,18R,19S,20S)-6-{[(tert-butoxy)carbonyl]oxy}-17-hydroxy-18-methoxy-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8-tetraene-19-carboxylate (1535203-28-1) → methyl (1R,15S,17R,18R,19S,20S)-6-{[(tert-butoxy)carbonyl]oxy}-17-({4-[(ethoxycarbonyl)oxy]-3,5-dimethoxyphenyl}carbonyloxy)-18-methoxy-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8-tetraene-19-carboxylate (1535202-89-1)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 15 - 30 ℃; for 20h; Inert atmosphere;

Reference yield:

(1S,2S,4R,18S,20R,23R)-9-hydroxy-23-methoxy-21-oxa-6,16-diazahexacyclo[18.2.1.02'18.04'16.05'13.07'12]tricosa-5(13),7,9,11-tetraen-22-one (866412-74-0) → methyl (1R,15S,17R,18R,19S,20S)-6-{[(tert-butoxy)carbonyl]oxy}-17-({4-[(ethoxycarbonyl)oxy]-3,5-dimethoxyphenyl}carbonyloxy)-18-methoxy-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8-tetraene-19-carboxylate (1535202-89-1)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap / N,N-dimethyl-formamide / 1 h / 35 °C / Inert atmosphere

2: sodium methylate / 1 h / 65 °C / Inert atmosphere

3: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 h / 15 - 30 °C / Inert atmosphere

With dmap; sodium methylate; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

tert-butyl (1S,2S,4R,18S,20R,23R)-23-methoxy-22-oxo-21-oxa-6,16-diazahexacyclo[18.2.1.02,18.04,16.05,13 .07,12]tricosa-5(13),7,9,11-tetraen-9-yl carbonate → methyl (1R,15S,17R,18R,19S,20S)-6-{[(tert-butoxy)carbonyl]oxy}-17-({4-[(ethoxycarbonyl)oxy]-3,5-dimethoxyphenyl}carbonyloxy)-18-methoxy-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8-tetraene-19-carboxylate (1535202-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate / 1 h / 65 °C / Inert atmosphere

2: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 h / 15 - 30 °C / Inert atmosphere

With dmap; sodium methylate; dicyclohexyl-carbodiimide; In dichloromethane;

upstream raw materials:

4-[(ethoxycarbonyl)oxy]-3,5-dimethoxybenzoic acid

methyl (1R,15S,17R,18R,19S,20S)-6-{[(tert-butoxy)carbonyl]oxy}-17-hydroxy-18-methoxy-3,13-diazapentacyclo[11.8.0.0^2,10.0^4,9.0^15,20]henicosa-2⁽¹⁰⁾,4,6,8-tetraene-19-carboxylate

(1S,2S,4R,18S,20R,23R)-9-hydroxy-23-methoxy-21-oxa-6,16-diazahexacyclo[18.2.1.0²'¹⁸.0⁴'¹⁶.0⁵'¹³.0⁷'¹²]tricosa-5⁽¹³⁾,7,9,11-tetraen-22-one

di-tert-butyl dicarbonate

Downstream raw materials:

methyl (1R,15S,17R,18R,19S,20S)-17-({4-[(ethoxycarbonyl)oxy]-3,5-dimethoxyphenyl}carbonyloxy)-6-hydroxy-18-methoxy-3,13-diazapentacyclo[11.8.0.0^2,10.0^4,9.0^15,20]henicosa-2⁽¹⁰⁾,4,6,8-tetraene-19-carboxylate

methyl (1R,15S,17R,18R,19S,20S)-6-(acetyloxy)-17-({4-[(ethoxycarbonyl)oxy]-3,5-dimethoxyphenyl}carbonyloxy)-18-methoxy-3,13-diazapentacyclo[11.8.0.0^2,10.0^4,9.0^15,20]henicosa-2⁽¹⁰⁾,4,6,8-tetraene-19-carboxylate

methyl (1R,15S,17R,18R,19S,20S)-6-(benzoyloxy)-17-({4-[(ethoxycarbonyl)oxy]-3,5-dimethoxyphenyl}carbonyloxy)-18-methoxy-3,13-diazapentacyclo[11.8.0.0^2,10.0^4,9.0^15,20]henicosa-2⁽¹⁰⁾,4,6,8-tetraene-19-carboxylate

methyl (1R,15S,17R,18R,19S,20S)-6-[(2-{[(tertbutoxy)carbonyl]amino}acetyl)oxy]-17-({4-[(ethoxycarbonyl)oxy]-3,5-dimethoxyphenyl}carbonyloxy)-18-methoxy-3,13-diazapentacyclo[11.8.0.0^2,10.0^4,9.0^15,20]henicosa-2⁽¹⁰⁾,4,6,8-tetraene-19-carboxylate

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