2-(5-amino-2-bromophenyl)-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Base Information

Chemical Name:2-(5-amino-2-bromophenyl)-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one
CAS No.:159547-23-6
Molecular Formula:C₂₉H₃₃BrFN₅O₃S
Molecular Weight:630.581
Hs Code.:

Synonyms:2-(5-amino-2-bromophenyl)-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one

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Chemical Property of 2-(5-amino-2-bromophenyl)-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one

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Technology Process of 2-(5-amino-2-bromophenyl)-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one

There total 9 articles about 2-(5-amino-2-bromophenyl)-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 159547-22-5
2-(2-bromo-5-nitrophenyl)-5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

: 159547-23-6
2-(5-amino-2-bromophenyl)-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: With hydrogen; platinum(IV) oxide; In ethanol; ethyl acetate; for 2h; under 1520 Torr;
DOI:10.1021/jm00019a004

Reference yield:

: tin(II)chloride dihydrate

: 159547-22-5
2-(2-bromo-5-nitrophenyl)-5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

: 159547-23-6
2-(5-amino-2-bromophenyl)-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; hydrogenchloride; ethyl acetate;

Reference yield:

: 51436-99-8
2-fluoro-4-bromotoluene

: 159547-23-6
2-(5-amino-2-bromophenyl)-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / aq. NaOH, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / ethanol / 4.5 h / 90 °C

2: Br₂ / CCl₄ / Heating; Irradiation

3: 1.) NaH / 1.) DMF, RT, 3.5 h, 2.) DMF, 35 deg C, 24 h

4: H₂ / PtO₂ / ethanol; ethyl acetate / 2 h / 1520 Torr

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; bromine; sodium hydride; platinum(IV) oxide; In tetrachloromethane; ethanol; ethyl acetate;
DOI:10.1021/jm00019a004