1-BOC-3-IODO-PIPERIDINE

Base Information

• Chemical Name: 1-BOC-3-IODO-PIPERIDINE
• CAS No.: 850761-36-3
• Molecular Formula: C₁₀H₁₈INO₂
• Molecular Weight: 311.163
• Mol file: 850761-36-3.mol

Synonyms:1-BOC-3-IODO-PIPERIDINE

Chemical Property of 1-BOC-3-IODO-PIPERIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 64-67℃
• Refractive Index: 1.542
• Boiling Point: 318.841°C at 760 mmHg
• PKA: -2.78±0.40(Predicted)
• Flash Point: 146.63°C
• PSA: 29.54000
• Density: 1.50
• LogP: 2.75880
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-3-iodo-piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-3-IODO-PIPERIDINE

There total 9 articles about 1-BOC-3-IODO-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-(tert-butyloxycarbonyl)nipecotic acid (71381-75-4,88495-54-9,84358-12-3) → tert-butyl 3-iodo-1-piperidinecarboxylate (850761-36-3,1354004-63-9,1354010-37-9)

Guidance literature:

With [bis(acetoxy)iodo]benzene; iodine; In tetrachloromethane; at 80 ℃; for 6h; Irradiation;

DOI:10.1002/ejoc.200400698

Reference yield: 70.0%

C19H22N2O6 → tert-butyl 3-iodo-1-piperidinecarboxylate (850761-36-3,1354004-63-9,1354010-37-9)

Guidance literature:

With triphenylphosphine; lithium iodide; In acetone; at 28 ℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.0c03173

Reference yield: 38.0%

(2S*,3R*)-tert-butyl 3-iodo-2-methoxypiperidine-1-carboxylate → tert-butyl 3-iodo-1-piperidinecarboxylate (850761-36-3,1354004-63-9,1354010-37-9)

Guidance literature:

With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at -90 - 20 ℃;

DOI:10.1002/adsc.202000450

upstream raw materials:

N-(tert-butyloxycarbonyl)nipecotic acid

di-tert-butyl dicarbonate

nipecotic acid

1-(tert-Butoxycarbonyl)-3-(methanesulfonyloxy)piperidine

Downstream raw materials:

1-propyl-3-(3-hydroxyphenyl)piperidine

(+/-)-3-(3-methoxyphenyl)-N-n-propylpiperidine

3-(3-methoxyphenylpiperidine)