[5-({4-[(3-{4-[3-({4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexylmethyl}-amino)-propyl]-piperazin-1-yl}-propylamino)-methyl]-cyclohexylmethyl}-carbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[5-({4-[(3-{4-[3-({4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexylmethyl}-amino)-propyl]-piperazin-1-yl}-propylamino)-methyl]-cyclohexylmethyl}-carbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid tert-butyl ester
CAS No.:240429-15-6
Molecular Formula:C₅₈H₁₁₀N₁₀O₁₀
Molecular Weight:1107.57
Hs Code.:

[5-({4-[(3-{4-[3-({4-[(2,6-bis-<i>tert</i>-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexylmethyl}-amino)-propyl]-piperazin-1-yl}-propylamino)-methyl]-cyclohexylmethyl}-carbamoyl)-5-<i>tert</i>-butoxycarbonylamino-pentyl]-carbamic acid <i>tert</i>-butyl ester

Synonyms:[5-({4-[(3-{4-[3-({4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexylmethyl}-amino)-propyl]-piperazin-1-yl}-propylamino)-methyl]-cyclohexylmethyl}-carbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid tert-butyl ester

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Chemical Property of [5-({4-[(3-{4-[3-({4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexylmethyl}-amino)-propyl]-piperazin-1-yl}-propylamino)-methyl]-cyclohexylmethyl}-carbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid tert-butyl ester

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Technology Process of [5-({4-[(3-{4-[3-({4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexylmethyl}-amino)-propyl]-piperazin-1-yl}-propylamino)-methyl]-cyclohexylmethyl}-carbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid tert-butyl ester

There total 7 articles about [5-({4-[(3-{4-[3-({4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexylmethyl}-amino)-propyl]-piperazin-1-yl}-propylamino)-methyl]-cyclohexylmethyl}-carbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [5-({4-[(3-{4-[3-({4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexylmethylene}-amino)-propyl]-piperazin-1-yl}-propylimino)-methyl]-cyclohexylmethyl}-carbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid tert-butyl ester

: 240429-15-6
[5-({4-[(3-{4-[3-({4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexylmethyl}-amino)-propyl]-piperazin-1-yl}-propylamino)-methyl]-cyclohexylmethyl}-carbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: With sodium tetrahydroborate; In dichloromethane; for 12h; Yield given; Ambient temperature;
DOI:10.1016/S0960-894X(99)00226-7

Reference yield:

: 7209-38-3
1,4-bis(3-aminopropyl)piperazine

: 240429-15-6
[5-({4-[(3-{4-[3-({4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexylmethyl}-amino)-propyl]-piperazin-1-yl}-propylamino)-methyl]-cyclohexylmethyl}-carbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: molecular sieves / 12 h / Ambient temperature

2: NaBH₄ / CH₂Cl₂ / 12 h / Ambient temperature

With sodium tetrahydroborate; molecular sieve; In dichloromethane;
DOI:10.1016/S0960-894X(99)00226-7

Reference yield:

: 1197-18-8
trans-4-aminomethyl-cyclohexyl-carboxylic acid

: 240429-15-6
[5-({4-[(3-{4-[3-({4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexylmethyl}-amino)-propyl]-piperazin-1-yl}-propylamino)-methyl]-cyclohexylmethyl}-carbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / N-hydroxysuccinimide, DCC / CH₂Cl₂ / 12 h / 0 - 4 °C

2: 1.) cyanuric fluoride, pyridine, 2.) NaBH₄, MeOH / 1.) CH₂Cl₂, 0 deg C, 2 h, 2.) CH₂Cl₂, RT, 5 h

3: 95 percent / PCC, SiO₂ / CH₂Cl₂ / 5 h / Ambient temperature

4: molecular sieves / 12 h / Ambient temperature

5: NaBH₄ / CH₂Cl₂ / 12 h / Ambient temperature

With pyridine; methanol; sodium tetrahydroborate; 1-hydroxy-pyrrolidine-2,5-dione; trifluoro-[1,3,5]triazine; molecular sieve; silica gel; dicyclohexyl-carbodiimide; pyridinium chlorochromate; In dichloromethane;
DOI:10.1016/S0960-894X(99)00226-7