4-(4-Acetylaminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylendioxyphthalazine

Base Information

• Chemical Name: 4-(4-Acetylaminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylendioxyphthalazine
• CAS No.: 186252-57-3
• Molecular Formula: C₂₂H₂₄N₄O₄
• Molecular Weight: 408.457
• Mol file: 186252-57-3.mol

Synonyms:4-(4-Acetylaminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylendioxyphthalazine

Chemical Property of 4-(4-Acetylaminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylendioxyphthalazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-Acetylaminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylendioxyphthalazine

There total 6 articles about 4-(4-Acetylaminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylendioxyphthalazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Propyl isocyanate (110-78-1) + 4-(4-acetylaminophenyl)-1,2-dihydro-1-methyl-6,7-methylenedioxyphthalazine (173952-39-1) → 4-(4-Acetylaminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylendioxyphthalazine (186252-57-3)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1021/jm950740w

Reference yield:

1-(4-acetylaminophenyl)-6,7-methylenedioxyphthalazine (173952-38-0) → 4-(4-Acetylaminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylendioxyphthalazine (186252-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1: TMEDA / tetrahydrofuran

2: CH₂Cl₂ / 20 °C

With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm950740w

Reference yield:

1-(4-aminophenyl)-6,7-methylenedioxyphthalazine (173952-37-9) → 4-(4-Acetylaminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylendioxyphthalazine (186252-57-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / 3 h / 20 °C

2: TMEDA / tetrahydrofuran

3: CH₂Cl₂ / 20 °C

With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm950740w

upstream raw materials:

Propyl isocyanate

4-(4-acetylaminophenyl)-1,2-dihydro-1-methyl-6,7-methylenedioxyphthalazine

5-bromo-6-(1,3-dioxolan-2-yl)benzo[d][1,3]dioxolane

1-(4-aminophenyl)-6,7-methylenedioxyphthalazine

Downstream raw materials:

SYM 2206