S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(carbamoylmethyl)sulfoximide

Base Information

Chemical Name:S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(carbamoylmethyl)sulfoximide
CAS No.:1147096-14-7
Molecular Formula:C₂₂H₁₉Cl₂N₅O₄S
Molecular Weight:520.396
Hs Code.:

Synonyms:S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(carbamoylmethyl)sulfoximide

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Chemical Property of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(carbamoylmethyl)sulfoximide

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Technology Process of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(carbamoylmethyl)sulfoximide

There total 10 articles about S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(carbamoylmethyl)sulfoximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 144-48-9
iodacetamide

: 1147095-59-7,1147096-64-7
S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl sulfoximide

: 1147096-14-7
S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(carbamoylmethyl)sulfoximide

Guidance literature:: S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl sulfoximide; With sodium hydride; In N,N-dimethyl-formamide; at 25 - 45 ℃; for 3h; Inert atmosphere;

iodacetamide; In N,N-dimethyl-formamide; at 0 - 30 ℃; for 12h;

Reference yield:

: 3795-79-7
methyl 4-(methylthio)benzoate

: 1147096-14-7
S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(carbamoylmethyl)sulfoximide

Guidance literature:: Multi-step reaction with 8 steps

1.1: vanadia / acetonitrile / -25 - -20 °C / Inert atmosphere

1.2: 25 - 30 °C

2.1: sodium azide; sulfuric acid / chloroform / 15 h / -20 - 50 °C / Inert atmosphere

3.1: pyridine / dichloromethane / 3 h / 15 - 30 °C / Inert atmosphere

4.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 25 - 30 °C

4.2: 0 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 10 - 30 °C / Inert atmosphere

6.1: tetrahydrofuran / 12 h / 10 - 30 °C / Inert atmosphere

7.1: sulfuric acid / 0 - 5 °C

8.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 25 - 45 °C / Inert atmosphere

8.2: 12 h / 0 - 30 °C

With pyridine; sodium azide; oxalyl dichloride; sulfuric acid; water; vanadia; sodium hydride; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1147096-52-3
methyl 4-(N-((benzyloxy)carbonyl)-S-methylsulfonimidoyl)benzoate

: 1147096-14-7
S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(carbamoylmethyl)sulfoximide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 25 - 30 °C

1.2: 0 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 10 - 30 °C / Inert atmosphere

3.1: tetrahydrofuran / 12 h / 10 - 30 °C / Inert atmosphere

4.1: sulfuric acid / 0 - 5 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 25 - 45 °C / Inert atmosphere

5.2: 12 h / 0 - 30 °C

With oxalyl dichloride; sulfuric acid; water; sodium hydride; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;