5,6-dimethyl-3-[(2'-phenyl-5'-methyl-1H-indol-3'-yl)methyleneamino]-thieno[2,3-d]pyrimidin-4(3H)-one

Base Information

• Chemical Name: 5,6-dimethyl-3-[(2'-phenyl-5'-methyl-1H-indol-3'-yl)methyleneamino]-thieno[2,3-d]pyrimidin-4(3H)-one
• CAS No.: 1394139-36-6
• Molecular Formula: C₂₄H₂₀N₄OS
• Molecular Weight: 412.515

Synonyms:5,6-dimethyl-3-[(2'-phenyl-5'-methyl-1H-indol-3'-yl)methyleneamino]-thieno[2,3-d]pyrimidin-4(3H)-one

Chemical Property of 5,6-dimethyl-3-[(2'-phenyl-5'-methyl-1H-indol-3'-yl)methyleneamino]-thieno[2,3-d]pyrimidin-4(3H)-one

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Technology Process of 5,6-dimethyl-3-[(2'-phenyl-5'-methyl-1H-indol-3'-yl)methyleneamino]-thieno[2,3-d]pyrimidin-4(3H)-one

There total 3 articles about 5,6-dimethyl-3-[(2'-phenyl-5'-methyl-1H-indol-3'-yl)methyleneamino]-thieno[2,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-amino-4,5-dimethyl-3-{N1-[(2'-phenyl-5'-methyl-1H-indol-3'-yl)methylene]}thieno-3-carbohydrazide (1394139-24-2) + orthoformic acid triethyl ester (122-51-0) → 5,6-dimethyl-3-[(2'-phenyl-5'-methyl-1H-indol-3'-yl)methyleneamino]-thieno[2,3-d]pyrimidin-4(3H)-one (1394139-36-6)

Guidance literature:

In acetic anhydride; for 7h; Reflux;

DOI:10.1007/s12039-011-0180-6

Reference yield:

5-methyl-2-phenyl-1H-indole-3-carboxaldehyde (41019-13-0) → 5,6-dimethyl-3-[(2'-phenyl-5'-methyl-1H-indol-3'-yl)methyleneamino]-thieno[2,3-d]pyrimidin-4(3H)-one (1394139-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 3 h / Reflux

2: acetic anhydride / 7 h / Reflux

In ethanol; acetic anhydride;

DOI:10.1007/s12039-011-0180-6

Reference yield:

2-amino-4,5-dimethyl-thiophene-3-carbohydrazide (1355234-13-7) → 5,6-dimethyl-3-[(2'-phenyl-5'-methyl-1H-indol-3'-yl)methyleneamino]-thieno[2,3-d]pyrimidin-4(3H)-one (1394139-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 3 h / Reflux

2: acetic anhydride / 7 h / Reflux

In ethanol; acetic anhydride;

DOI:10.1007/s12039-011-0180-6

upstream raw materials:

2-amino-4,5-dimethyl-thiophene-3-carbohydrazide

2-amino-4,5-dimethyl-3-{N₁-[(2'-phenyl-5'-methyl-1H-indol-3'-yl)methylene]}thieno-3-carbohydrazide

orthoformic acid triethyl ester

5-methyl-2-phenyl-1H-indole-3-carboxaldehyde

Downstream raw materials:

5,6-dimethyl-3-[2-(2'-phenyl-5'-methyl-1H-indol-3-yl)-4-oxothiazolidin-3-yl]thieno[2,3-d]pyrimidin-4(3H)-one

5,6-dimethyl-3-[3-chloro-2-(2'-phenyl-5'-methyl-1H-indol-3'-yl)-4-oxoazetidin-1-yl]-thieno[2,3-d]pyrimidin-4(3H)-one

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