41019-13-0

Usage

Type of compound

Aldehyde derivative of indole

Aromatic heterocyclic compound

Yes

Functional groups

One aldehyde group, one methyl group, and one phenyl group

Reactivity

Diverse and high

Common use

Synthesis of pharmaceuticals and organic compounds

Biological activities

Interesting and potential therapeutic applications

Safety concerns

Toxic and harmful if not used properly

Upstream product

• 13228-36-9 5-methyl-2-phenyl-1H-indole 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 82451-02-3 5-Methyl-2-phenyl-1H-indole-3-carbaldehyde oxime 
• 136230-33-6 (E)-3-(5-Methyl-2-phenyl-1H-indol-3-yl)-1-phenyl-propenone 
• 120607-73-0 (E)-2-Cyano-3-(5-methyl-2-phenyl-1H-indol-3-yl)-acrylic acid ethyl ester 
• 120607-83-2 2-(5-Methyl-2-phenyl-1H-indol-3-ylmethylene)-malononitrile 
• 679836-34-1 coumarin-(5'-methyl-2'-phenylindole-3'-carboxaldehyde)-3-carbonylhydrazone 
• 211749-80-3 2-[(5-Methyl-2-phenyl-1H-indol-3-ylmethyl)-amino]-phenol 
• 94674-46-1 5-methyl-2-phenyl-indole-3-carbaldehyde thiosemicarbazone 
• 1198475-82-9 C₂₄H₁₈ClNO 
• 263891-63-0 C₂₅H₂₁NO 
• 1347738-22-0 (Z)-5-((5-methyl-2-phenyl-1H-indol-3-yl)methylene)thiazolidine-2,4-dione 
• 1347738-18-4 5-((5-methyl-2-phenyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1347738-20-8 5-((5-methyl-2-phenyl-1H-indol-3-yl)methylene)-dihydro-2-thioxopyrimidine-4,6(1H,5H)-dione 
• 1347738-24-2 (4E)-3-methyl-4-((5-methyl-2-phenyl-1H-indol-3-yl)methylene)-1H-pyrazol-5(4H)-one 
• 1394139-24-2 2-amino-4,5-dimethyl-3-{N₁-[(2'-phenyl-5'-methyl-1H-indol-3'-yl)methylene]}thieno-3-carbohydrazide 

Relevant academic research and scientific papers

An Efficient, Eco-Friendly Synthesis of Pyran Annulated Indole Analogs under Conventional Heating and Microwave Irradiation, and Their Anticancer and Antioxidant Activity

A rapid, facile, green, eco-friendly, cost effective, and efficient method for the synthesis of pyran annulated indole analogs via one-pot, three components reaction is developed. According to the developed method 2,5-disubstituted-1H-indol-3-carboxaldehyde, malononitrile and various phenols react under MW assisted solvent-free conditions. These compounds can be also prepared under a conventional method that is characterized by some disadvantages in comparison with the above approach. Structures of products are confirmed by FT-IR, 1H and 13C NMR, and mass spectral data. The in vitro antioxidant and cytotoxic activities of the products are evaluated against three tumor cell lines and discussed in terms of structure―activity analysis. Among the screened compounds 3d, 4a, 4b, 5a, and 5b exhibit excellent antioxidant activity. Compounds 4b, 5a, and 5b demonstrate strong cytotoxic activity.

Chiral Phosphoric Acid Catalyzed Intramolecular Dearomative Michael Addition of Indoles to Enones

An enantioselective intramolecular dearomative Michael addition of indolyl enones is presented. In the presence of catalytic amount of chiral phosphoric acid, various enantioenriched spiro-indolenines bearing a quaternary stereogenic center were obtained

Synthesis, antioxidant and DNA cleavage activities of novel indole derivatives

A new series of novel indole derivatives containing barbitone moiety (5a-i) are synthesized by simple and efficient condensation of chalcones (3a-i) with barbituric acid (4). The synthesized compounds are screened for their antioxidant (free radical scave

A New Route to Indoloisoquinolines

2-Phenylindole-3-carbaldoximes (2a-d) on cyclization with alcoholic sulphuric acid give δ-carbolines, indolo-isoquinolines (5a-d) and not the γ-carbolines.This constitutes a new route to δ-carbolines.