9-<3'-azido-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-xylofuranosyl>-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenin 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>

Base Information

• Chemical Name: 9-<3'-azido-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-xylofuranosyl>-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenin 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>
• CAS No.: 127950-03-2
• Molecular Formula: C₅₃H₄₅Cl₂N₁₀O₁₃P
• Molecular Weight: 1131.88

Synonyms:9-<3'-azido-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-xylofuranosyl>-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenin 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>

Chemical Property of 9-<3'-azido-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-xylofuranosyl>-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenin 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>

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Technology Process of 9-<3'-azido-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-xylofuranosyl>-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenin 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>

There total 7 articles about 9-<3'-azido-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-xylofuranosyl>-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenin 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-(3'-azido-3'-deoxy-β-D-xylofuranosyl)adenine (51014-75-6) → 9-<3'-azido-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-xylofuranosyl>-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenin 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate> (127950-03-2)

Guidance literature:

Multi-step reaction with 5 steps

1: (NH₄)2SO₄ / dioxane / 3 h / Heating

2: CH₂Cl₂ / 36 h / Ambient temperature

3: aq. NH₃ / methanol / 0.75 h / Ambient temperature

4: 94 percent / pyridine / 48 h / Ambient temperature

5: 1.) 1,2,4-triazole / 1.) pyridine, 30 min; 2.) r.t., overnight

With 1,2,4-Triazole; ammonium sulfate; ammonium hydroxide; In 1,4-dioxane; pyridine; methanol; dichloromethane;

DOI:10.1002/hlca.19890720810

Reference yield:

1-methyl-3-[2-(4-nitrophenyl)ethoxycarbonyl]imidazolium chloride (88091-70-7) → 9-<3'-azido-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-xylofuranosyl>-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenin 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate> (127950-03-2)

Guidance literature:

Multi-step reaction with 4 steps

1: CH₂Cl₂ / 36 h / Ambient temperature

2: aq. NH₃ / methanol / 0.75 h / Ambient temperature

3: 94 percent / pyridine / 48 h / Ambient temperature

4: 1.) 1,2,4-triazole / 1.) pyridine, 30 min; 2.) r.t., overnight

With 1,2,4-Triazole; ammonium hydroxide; In pyridine; methanol; dichloromethane;

DOI:10.1002/hlca.19890720810

Reference yield:

9-((2R,3R,4S,5S)-4-Azido-3-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine → 9-<3'-azido-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-xylofuranosyl>-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenin 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate> (127950-03-2)

Guidance literature:

Multi-step reaction with 4 steps

1: CH₂Cl₂ / 36 h / Ambient temperature

2: aq. NH₃ / methanol / 0.75 h / Ambient temperature

3: 94 percent / pyridine / 48 h / Ambient temperature

4: 1.) 1,2,4-triazole / 1.) pyridine, 30 min; 2.) r.t., overnight

With 1,2,4-Triazole; ammonium hydroxide; In pyridine; methanol; dichloromethane;

DOI:10.1002/hlca.19890720810

upstream raw materials:

2-(4-nitrophenyl)ethanol

2,5-dichlorophenyl phosphorodichloridate

9-<3'-azido-3'-deoxy-5'-O-(monomethoxytrityl)-β-D-xylofuranosyl>-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenine

9-(3'-azido-3'-deoxy-β-D-xylofuranosyl)adenine

Downstream raw materials:

9-<3'-azido-3'-deoxy-β-D-xylofuranosyl>-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenin 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>

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