2',3',5'-tri-O-acetyl-O⁶-(2,4,6-triisopropylbenzenesulfonyl)-N²-tritylguanosine

Base Information

• Chemical Name: 2',3',5'-tri-O-acetyl-O⁶-(2,4,6-triisopropylbenzenesulfonyl)-N²-tritylguanosine
• CAS No.: 77001-23-1
• Molecular Formula: C₅₀H₅₅N₅O₁₀S
• Molecular Weight: 918.08

Synonyms:2',3',5'-tri-O-acetyl-O⁶-(2,4,6-triisopropylbenzenesulfonyl)-N²-tritylguanosine

Chemical Property of 2',3',5'-tri-O-acetyl-O⁶-(2,4,6-triisopropylbenzenesulfonyl)-N²-tritylguanosine

Chemical Property:

Purity/Quality:

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Technology Process of 2',3',5'-tri-O-acetyl-O⁶-(2,4,6-triisopropylbenzenesulfonyl)-N²-tritylguanosine

There total 2 articles about 2',3',5'-tri-O-acetyl-O⁶-(2,4,6-triisopropylbenzenesulfonyl)-N²-tritylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2,4,6-triisopropylphenylsulfonyl chloride (6553-96-4) + 2',3',5'-tri-O-acetyl-N2-tritylguanosine (69471-51-8) → 2',3',5'-tri-O-acetyl-O6-(2,4,6-triisopropylbenzenesulfonyl)-N2-tritylguanosine (77001-23-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 3h;

Reference yield:

2,4,6-triisopropylphenylsulfonyl chloride (6553-96-4) + 2',3',5'-Tri-O-acetyl-N2-tritylguanosine (69471-51-8) → Acetic acid (3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[6-(2,4,6-triisopropyl-benzenesulfonyloxy)-2-(trityl-amino)-purin-9-yl]-tetrahydro-furan-3-yl ester (77001-23-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 12h; Yield given; Ambient temperature;

DOI:10.1016/0040-4039(80)80211-5

Reference yield: 100.0%

Acetic acid (3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[6-(2,4,6-triisopropyl-benzenesulfonyloxy)-2-(trityl-amino)-purin-9-yl]-tetrahydro-furan-3-yl ester (77001-23-1) → Acetic acid (3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[2-amino-6-(2,4,6-triisopropyl-benzenesulfonyloxy)-purin-9-yl]-tetrahydro-furan-3-yl ester (76994-81-5)

Guidance literature:

With acetic acid; In 1,4-dioxane; water; for 1h; Product distribution; Ambient temperature;

DOI:10.1016/0040-4039(80)80211-5

upstream raw materials:

2,4,6-triisopropylphenylsulfonyl chloride

2',3',5'-Tri-O-acetyl-N²-tritylguanosine

2',3',5'-tri-O-acetyl-N²-tritylguanosine

Downstream raw materials:

Acetic acid (3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[2-amino-6-(2,4,6-triisopropyl-benzenesulfonyloxy)-purin-9-yl]-tetrahydro-furan-3-yl ester

2,4,6-Triisopropyl-benzenesulfonate1-[9-((2R,3R,4R,5R)-3,4-diacetoxy-5-acetoxymethyl-tetrahydro-furan-2-yl)-2-(trityl-amino)-9H-purin-6-yl]-pyridinium;

Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[2-amino-6-(2,4,6-triisopropyl-benzenesulfonyloxy)-purin-9-yl]-tetrahydro-furan-3-yl ester

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