dimethyl 2-[6-(2-bromophenyl)-6-tert-butyldimethylsilyloxy-3-hexynyl]malonate

Base Information

Chemical Name:dimethyl 2-[6-(2-bromophenyl)-6-tert-butyldimethylsilyloxy-3-hexynyl]malonate
CAS No.:1379038-67-1
Molecular Formula:C₂₃H₃₃BrO₅Si
Molecular Weight:497.502
Hs Code.:

Synonyms:dimethyl 2-[6-(2-bromophenyl)-6-tert-butyldimethylsilyloxy-3-hexynyl]malonate

Suppliers and Price of dimethyl 2-[6-(2-bromophenyl)-6-tert-butyldimethylsilyloxy-3-hexynyl]malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of dimethyl 2-[6-(2-bromophenyl)-6-tert-butyldimethylsilyloxy-3-hexynyl]malonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of dimethyl 2-[6-(2-bromophenyl)-6-tert-butyldimethylsilyloxy-3-hexynyl]malonate

There total 4 articles about dimethyl 2-[6-(2-bromophenyl)-6-tert-butyldimethylsilyloxy-3-hexynyl]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1379038-87-5
C₁₈H₂₆Br₂OSi

: 108-59-8
malonic acid dimethyl ester

: 1379038-67-1
dimethyl 2-[6-(2-bromophenyl)-6-tert-butyldimethylsilyloxy-3-hexynyl]malonate

Guidance literature:: malonic acid dimethyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

C₁₈H₂₆Br₂OSi; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1021/ol301257m

Reference yield:

: 1258636-22-4
[1-(2-bromophenyl)but-3-ynyloxy](tert-butyl)dimethylsilane

: 1379038-67-1
dimethyl 2-[6-(2-bromophenyl)-6-tert-butyldimethylsilyloxy-3-hexynyl]malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C

1.2: 3 h / -40 °C

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 80 °C

With n-butyllithium; carbon tetrabromide; sodium hydride; diisopropylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol301257m

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 1379038-67-1
dimethyl 2-[6-(2-bromophenyl)-6-tert-butyldimethylsilyloxy-3-hexynyl]malonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C

3.2: 3 h / -40 °C

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

5.2: 80 °C

With 1H-imidazole; n-butyllithium; carbon tetrabromide; sodium hydride; diisopropylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol301257m