2-{2-[3-(carboxymethyl)-5-(4-hydroxy-3-methoxyphenyl)thiophen-2-yl]-5-(4-hydroxy-3-methoxyphenyl)thiophen-3-yl}acetic acid

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Chemical Name:2-{2-[3-(carboxymethyl)-5-(4-hydroxy-3-methoxyphenyl)thiophen-2-yl]-5-(4-hydroxy-3-methoxyphenyl)thiophen-3-yl}acetic acid
CAS No.:1419170-52-7
Molecular Formula:C₂₆H₂₂O₈S₂
Molecular Weight:526.588
Hs Code.:

Synonyms:2-{2-[3-(carboxymethyl)-5-(4-hydroxy-3-methoxyphenyl)thiophen-2-yl]-5-(4-hydroxy-3-methoxyphenyl)thiophen-3-yl}acetic acid

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Chemical Property of 2-{2-[3-(carboxymethyl)-5-(4-hydroxy-3-methoxyphenyl)thiophen-2-yl]-5-(4-hydroxy-3-methoxyphenyl)thiophen-3-yl}acetic acid

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Technology Process of 2-{2-[3-(carboxymethyl)-5-(4-hydroxy-3-methoxyphenyl)thiophen-2-yl]-5-(4-hydroxy-3-methoxyphenyl)thiophen-3-yl}acetic acid

There total 6 articles about 2-{2-[3-(carboxymethyl)-5-(4-hydroxy-3-methoxyphenyl)thiophen-2-yl]-5-(4-hydroxy-3-methoxyphenyl)thiophen-3-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1419172-41-0
C₂₈H₂₆O₈S₂

: 1419170-52-7
2-{2-[3-(carboxymethyl)-5-(4-hydroxy-3-methoxyphenyl)thiophen-2-yl]-5-(4-hydroxy-3-methoxyphenyl)thiophen-3-yl}acetic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; at 70 ℃; for 0.75h;

Reference yield:

: 58414-52-1
thiophen-3-yl-acetic acid methyl ester

: 1419170-52-7
2-{2-[3-(carboxymethyl)-5-(4-hydroxy-3-methoxyphenyl)thiophen-2-yl]-5-(4-hydroxy-3-methoxyphenyl)thiophen-3-yl}acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; acetic acid / chloroform / 72 h / 0 - 20 °C

2: potassium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bis(pinacol)diborane / toluene; methanol / 0.5 h / 80 °C / Inert atmosphere; Sealed tube

3: N-Bromosuccinimide; acetic acid / chloroform / 20 °C

4: [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium fluoride / toluene; methanol / 1.5 h / 55 °C / Inert atmosphere

5: sodium hydroxide / 1,4-dioxane; water / 0.75 h / 70 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; N-Bromosuccinimide; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; acetic acid; bis(pinacol)diborane; sodium hydroxide; In 1,4-dioxane; methanol; chloroform; water; toluene; 4: |Suzuki Coupling;

Reference yield:

: 1419171-83-7
methyl 2-{2-[3-(2-methoxy-2-oxoethyl)thiophen-2-yl]thiophen-3-yl}acetate

: 1419170-52-7
2-{2-[3-(carboxymethyl)-5-(4-hydroxy-3-methoxyphenyl)thiophen-2-yl]-5-(4-hydroxy-3-methoxyphenyl)thiophen-3-yl}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; acetic acid / chloroform / 20 °C

2: [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium fluoride / toluene; methanol / 1.5 h / 55 °C / Inert atmosphere

3: sodium hydroxide / 1,4-dioxane; water / 0.75 h / 70 °C

With potassium fluoride; N-Bromosuccinimide; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; acetic acid; sodium hydroxide; In 1,4-dioxane; methanol; chloroform; water; toluene; 2: |Suzuki Coupling;