Piperazino-acetic acid-benzylamide hydrochloride

Base Information

• Chemical Name: Piperazino-acetic acid-benzylamide hydrochloride
• CAS No.: 850415-38-2
• Molecular Formula: C13H19 N3 O . Cl H
• Molecular Weight: 269.774
• Hs Code.: 2933599090
• Mol file: 850415-38-2.mol

Synonyms:1-Piperazineacetamide,N-(phenylmethyl)-, monohydrochloride (9CI)

Chemical Property of Piperazino-acetic acid-benzylamide hydrochloride

Chemical Property:

• PSA: 44.37000
• LogP: 1.66760

Purity/Quality:

98%min ^*data from raw suppliers

PiperazinophenylaceticAcidBenzylamideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperazino-acetic acid-benzylamide hydrochloride

There total 4 articles about Piperazino-acetic acid-benzylamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-benzyl-2-chloroacetamide (2564-06-9) + piperazine hydrochloride (7542-23-6,8006-71-1) → N-benzyl-2-(piperazin-1-yl)acetamide hydrochloride (850415-38-2,827614-58-4)

Guidance literature:

In ethanol; at 50 ℃; for 2.5h; Reflux;

DOI:10.1016/j.cclet.2015.11.002

Reference yield:

tert-butyl 4-[(benzylcarbamoyl)methyl]piperazine-1-carboxylate (1401333-63-8) → N-benzyl-2-(piperazin-1-yl)acetamide hydrochloride (850415-38-2,827614-58-4)

Guidance literature:

With hydrogenchloride; water; In methanol; at 60 ℃; for 6h;

DOI:10.5012/bkcs.2012.33.8.2597

Reference yield:

benzylamine (100-46-9) → N-benzyl-2-(piperazin-1-yl)acetamide hydrochloride (850415-38-2,827614-58-4)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2: potassium carbonate / acetonitrile / 6 h / Reflux

3: hydrogenchloride; water / methanol / 6 h / 60 °C

With hydrogenchloride; water; potassium carbonate; triethylamine; In methanol; dichloromethane; acetonitrile;

DOI:10.5012/bkcs.2012.33.8.2597

upstream raw materials:

benzylamine

N-benzyl-2-bromoacetamide

tert-butyl 4-[(benzylcarbamoyl)methyl]piperazine-1-carboxylate

N-benzyl-2-chloroacetamide

Refernces

• 1、 Han, Minsoo,Han, Younghue,Song, Chiman,Hahn, Hoh-Gyu. "The design and synthesis of 1,4-substituted piperazine derivatives as triple reuptake inhibitors". . p. 2597 - 2602. Retrieved 2012/10/29.