4-ethoxythiocarbonylsulfanyl-5-(toluene-4-sulfonylamino)pentanoic acid methyl ester

Base Information

• Chemical Name: 4-ethoxythiocarbonylsulfanyl-5-(toluene-4-sulfonylamino)pentanoic acid methyl ester
• CAS No.: 851460-96-3
• Molecular Formula: C₁₆H₂₃NO₅S₃
• Molecular Weight: 405.56

Synonyms:4-ethoxythiocarbonylsulfanyl-5-(toluene-4-sulfonylamino)pentanoic acid methyl ester

Chemical Property of 4-ethoxythiocarbonylsulfanyl-5-(toluene-4-sulfonylamino)pentanoic acid methyl ester

Chemical Property:

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Technology Process of 4-ethoxythiocarbonylsulfanyl-5-(toluene-4-sulfonylamino)pentanoic acid methyl ester

There total 2 articles about 4-ethoxythiocarbonylsulfanyl-5-(toluene-4-sulfonylamino)pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethoxyrhiocarbonylsulfanylacetic acid methyl ester (123972-89-4) + 4-methyl-N-(2-propenyl)benzenesulfonamide (50487-71-3) → 4-ethoxythiocarbonylsulfanyl-5-(toluene-4-sulfonylamino)pentanoic acid methyl ester (851460-96-3)

Guidance literature:

With dilauryl peroxide; In 1,2-dichloro-ethane; Heating;

DOI:10.1021/ol0503642 DOI:10.1016/j.tet.2007.04.091

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 4-ethoxythiocarbonylsulfanyl-5-(toluene-4-sulfonylamino)pentanoic acid methyl ester (851460-96-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / NaOH / H₂O; diethyl ether / 5 h / 20 °C

2: 85 percent / lauroyl peroxide / 1,2-dichloro-ethane / Heating

With sodium hydroxide; dilauryl peroxide; In diethyl ether; water; 1,2-dichloro-ethane;

DOI:10.1021/ol0503642

Reference yield: 97.0%

4-ethoxythiocarbonylsulfanyl-5-(toluene-4-sulfonylamino)pentanoic acid methyl ester (851460-96-3) + acetic anhydride (108-24-7) → 5-[acetyl(toluene-4-sulfonyl)amino]4-ethoxythiocarbonylsulfanylpentanoic acid methyl ester (851461-04-6)

Guidance literature:

With pyridine;

DOI:10.1016/j.tet.2007.04.091

upstream raw materials:

ethoxyrhiocarbonylsulfanylacetic acid methyl ester

4-methyl-N-(2-propenyl)benzenesulfonamide

p-toluenesulfonyl chloride

Downstream raw materials:

5-[acetyl(toluene-4-sulfonyl)amino]4-ethoxythiocarbonylsulfanylpentanoic acid methyl ester

methyl 4-ethoxythiocarbonylsulfanyl-5-(N-methoxycarbonyl-N-(4-toluenesulfonyl)amino)pentanoate

methyl 4-ethoxythiocarbonylsulfanyl-5-(N-tert-butoxycarbonyl-N-(4-toluenesulfonyl)amino)pentanoate

5-acetylamino-4-p-toluenepentanoic acid methyl ester

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