tert-butyl 4-(((5-carbamoyl-4'-fluorobiphenyl-3-yl)methoxy)methyl)-4-phenylpiperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(((5-carbamoyl-4'-fluorobiphenyl-3-yl)methoxy)methyl)-4-phenylpiperidine-1-carboxylate
CAS No.:954124-76-6
Molecular Formula:C₃₁H₃₅FN₂O₄
Molecular Weight:518.628
Hs Code.:

Synonyms:tert-butyl 4-(((5-carbamoyl-4'-fluorobiphenyl-3-yl)methoxy)methyl)-4-phenylpiperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(((5-carbamoyl-4'-fluorobiphenyl-3-yl)methoxy)methyl)-4-phenylpiperidine-1-carboxylate

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Technology Process of tert-butyl 4-(((5-carbamoyl-4'-fluorobiphenyl-3-yl)methoxy)methyl)-4-phenylpiperidine-1-carboxylate

There total 1 articles about tert-butyl 4-(((5-carbamoyl-4'-fluorobiphenyl-3-yl)methoxy)methyl)-4-phenylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 954124-68-6
3-bromo-5-(((1-(tert-butoxycarbonyl)-4-phenylpiperidin-4-yl)methoxy)methyl)benzoic acid

: 1765-93-1
4-fluoroboronic acid

: 954124-76-6
tert-butyl 4-(((5-carbamoyl-4'-fluorobiphenyl-3-yl)methoxy)methyl)-4-phenylpiperidine-1-carboxylate

Guidance literature:: 3-bromo-5-(((1-(tert-butoxycarbonyl)-4-phenylpiperidin-4-yl)methoxy)methyl)benzoic acid; 4-fluoroboronic acid; With potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; at 120 ℃; for 1h; Sealed tube; Microwave irradiation;

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 1.5h;