3-bromo-5-(((1-(tert-butoxycarbonyl)-4-phenylpiperidin-4-yl)methoxy)methyl)benzoic acid

Base Information

Chemical Name:3-bromo-5-(((1-(tert-butoxycarbonyl)-4-phenylpiperidin-4-yl)methoxy)methyl)benzoic acid
CAS No.:954124-68-6
Molecular Formula:C₂₅H₃₀BrNO₅
Molecular Weight:504.421
Hs Code.:

Synonyms:3-bromo-5-(((1-(tert-butoxycarbonyl)-4-phenylpiperidin-4-yl)methoxy)methyl)benzoic acid

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Chemical Property of 3-bromo-5-(((1-(tert-butoxycarbonyl)-4-phenylpiperidin-4-yl)methoxy)methyl)benzoic acid

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Technology Process of 3-bromo-5-(((1-(tert-butoxycarbonyl)-4-phenylpiperidin-4-yl)methoxy)methyl)benzoic acid

There total 1 articles about 3-bromo-5-(((1-(tert-butoxycarbonyl)-4-phenylpiperidin-4-yl)methoxy)methyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 877624-40-3
methyl 3-bromo-5-(bromomethyl)benzoate

: 158144-85-5
1-t-butoxycarbonyl-4-phenyl-4-hydroxymethyl piperidine

: 954124-68-6
3-bromo-5-(((1-(tert-butoxycarbonyl)-4-phenylpiperidin-4-yl)methoxy)methyl)benzoic acid

Guidance literature:: methyl 3-bromo-5-(bromomethyl)benzoate; 1-t-butoxycarbonyl-4-phenyl-4-hydroxymethyl piperidine; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.5h;

With lithium hydroxide; water; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

With hydrogenchloride; In water; at 4 ℃; pH=~ 1;

Reference yield: 70.0%

: 954124-68-6
3-bromo-5-(((1-(tert-butoxycarbonyl)-4-phenylpiperidin-4-yl)methoxy)methyl)benzoic acid

: 124-40-3
dimethyl amine

: 954124-70-0
tert-butyl 4-((3-bromo-5-(dimethylcarbamoyl)benzyloxy)methyl)-4-phenylpiperidine-1-carboxylate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 1.5h;

Reference yield: 66.0%

: 954124-68-6
3-bromo-5-(((1-(tert-butoxycarbonyl)-4-phenylpiperidin-4-yl)methoxy)methyl)benzoic acid

: 1765-93-1
4-fluoroboronic acid

: 954124-76-6
tert-butyl 4-(((5-carbamoyl-4'-fluorobiphenyl-3-yl)methoxy)methyl)-4-phenylpiperidine-1-carboxylate

Guidance literature:: 3-bromo-5-(((1-(tert-butoxycarbonyl)-4-phenylpiperidin-4-yl)methoxy)methyl)benzoic acid; 4-fluoroboronic acid; With potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; at 120 ℃; for 1h; Sealed tube; Microwave irradiation;

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 1.5h;