(S)-(9H-fluoren-9-yl)methyl 1-(4-cyano-3-fluorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:(S)-(9H-fluoren-9-yl)methyl 1-(4-cyano-3-fluorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1430217-63-2
Molecular Formula:C₃₂H₂₄FN₃O₃
Molecular Weight:517.559
Hs Code.:

Synonyms:(S)-(9H-fluoren-9-yl)methyl 1-(4-cyano-3-fluorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of (S)-(9H-fluoren-9-yl)methyl 1-(4-cyano-3-fluorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Technology Process of (S)-(9H-fluoren-9-yl)methyl 1-(4-cyano-3-fluorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 2 articles about (S)-(9H-fluoren-9-yl)methyl 1-(4-cyano-3-fluorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 53312-80-4
4-amino-2-fluorobenzonitrile

: 204317-99-7
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

: 1430217-63-2
(S)-(9H-fluoren-9-yl)methyl 1-(4-cyano-3-fluorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With pyridine; trichlorophosphate; In dichloromethane; for 0.75h; Cooling with ice;

Reference yield:

: 34667-88-4
2-fluoro-4-nitrobenzonitrile

: 1430217-63-2
(S)-(9H-fluoren-9-yl)methyl 1-(4-cyano-3-fluorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol; acetonitrile / 1 h / 2585.81 Torr

2: pyridine; trichlorophosphate / dichloromethane / 0.75 h / Cooling with ice

With pyridine; palladium 10% on activated carbon; hydrogen; trichlorophosphate; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1430217-63-2
(S)-(9H-fluoren-9-yl)methyl 1-(4-cyano-3-fluorophenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1430216-43-5
(S,E)-N-(3-amino-1H-indazol-6-yl)-2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 0.58 h / 160 °C / Microwave irradiation

2: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / ethyl acetate; N,N-dimethyl-formamide

With hydrazine hydrate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In ethanol; ethyl acetate; N,N-dimethyl-formamide;