7-bromo-4-{5-[(4-fluorophenyl)methyl]-6-methylpyrimidin-4-yl}-2,3,4,5-tetrahydro-1,4-benzoxazepine

Base Information

• Chemical Name: 7-bromo-4-{5-[(4-fluorophenyl)methyl]-6-methylpyrimidin-4-yl}-2,3,4,5-tetrahydro-1,4-benzoxazepine
• CAS No.: 1256784-49-2
• Molecular Formula: C₂₁H₁₉BrFN₃O
• Molecular Weight: 428.304
• Mol file: 1256784-49-2.mol

Synonyms:7-bromo-4-{5-[(4-fluorophenyl)methyl]-6-methylpyrimidin-4-yl}-2,3,4,5-tetrahydro-1,4-benzoxazepine

Chemical Property of 7-bromo-4-{5-[(4-fluorophenyl)methyl]-6-methylpyrimidin-4-yl}-2,3,4,5-tetrahydro-1,4-benzoxazepine

Chemical Property:

Purity/Quality:

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Technology Process of 7-bromo-4-{5-[(4-fluorophenyl)methyl]-6-methylpyrimidin-4-yl}-2,3,4,5-tetrahydro-1,4-benzoxazepine

There total 1 articles about 7-bromo-4-{5-[(4-fluorophenyl)methyl]-6-methylpyrimidin-4-yl}-2,3,4,5-tetrahydro-1,4-benzoxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

7-bromo-2,3,4,5-tetrahydrobenzo[f ][1,4]oxazepine hydrochloride (740842-72-2) + 4-chloro-5-[(4-fluorophenyl)methyl]-6-methylpyrimidine (1256784-16-3) → 7-bromo-4-{5-[(4-fluorophenyl)methyl]-6-methylpyrimidin-4-yl}-2,3,4,5-tetrahydro-1,4-benzoxazepine (1256784-49-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 20h;

Reference yield: 5.0%

4-(1H-pyrazol-3-yl)phenylboronic acid (1174304-73-4,1226849-25-7) + 7-bromo-4-{5-[(4-fluorophenyl)methyl]-6-methylpyrimidin-4-yl}-2,3,4,5-tetrahydro-1,4-benzoxazepine (1256784-49-2) → 4-{5-[(4-fluorophenyl)methyl]-6-methylpyrimidin-4-yl}-7-[4-(1H-pyrazol-3-yl)phenyl]-2,3,4,5-tetrahydro-1,4-benzoxazepine (1256783-63-7)

Guidance literature:

With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In ISOPROPYLAMIDE; water; at 99 ℃; for 24h;

upstream raw materials:

7-bromo-2,3,4,5-tetrahydrobenzo[f ][1,4]oxazepine hydrochloride

4-chloro-5-[(4-fluorophenyl)methyl]-6-methylpyrimidine

Downstream raw materials:

4-{5-[(4-fluorophenyl)methyl]-6-methylpyrimidin-4-yl}-7-[4-(1H-pyrazol-3-yl)phenyl]-2,3,4,5-tetrahydro-1,4-benzoxazepine