7-bromo-2,3,4,5-tetrahydrobenzo[f ][1,4]oxazepine hydrochloride

Base Information

• Chemical Name: 7-bromo-2,3,4,5-tetrahydrobenzo[f ][1,4]oxazepine hydrochloride
• CAS No.: 740842-72-2
• Molecular Formula: C₉H₁₀BrNO*ClH
• Molecular Weight: 264.549
• Mol file: 740842-72-2.mol

Synonyms:7-bromo-2,3,4,5-tetrahydrobenzo[f ][1,4]oxazepine hydrochloride

Chemical Property of 7-bromo-2,3,4,5-tetrahydrobenzo[f ][1,4]oxazepine hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

7-Bromo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepinehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-bromo-2,3,4,5-tetrahydrobenzo[f ][1,4]oxazepine hydrochloride

There total 11 articles about 7-bromo-2,3,4,5-tetrahydrobenzo[f ][1,4]oxazepine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,1-dimethylethyl 7-bromo-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (740842-73-3) → 7-bromo-2,3,4,5-tetrahydrobenzo[f ][1,4]oxazepine hydrochloride (740842-72-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethanol; at 20 ℃; for 1h; Heating;

Reference yield: 75.0%

7-bromobenzo[f ][1,4]oxazepine-3,5(2H,4H)-dione → 7-bromo-2,3,4,5-tetrahydrobenzo[f ][1,4]oxazepine hydrochloride (740842-72-2)

Guidance literature:

7-bromobenzo[f ][1,4]oxazepine-3,5(2H,4H)-dione; With tetrahydrofuran; borane-THF; at 30 - 35 ℃; for 125.5h; Inert atmosphere; Large scale;

With methanol; at 45 ℃; Inert atmosphere; Large scale;

With hydrogenchloride; In water; at 20 - 50 ℃; for 14h; Inert atmosphere; Large scale;

DOI:10.1021/acs.oprd.5b00037

Reference yield: 67.0%

7-bromo-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one (5755-05-5) → 7-bromo-2,3,4,5-tetrahydrobenzo[f ][1,4]oxazepine hydrochloride (740842-72-2)

Guidance literature:

With borane dimethyl sulfide complex; In 1,2-dimethoxyethane; Heating / reflux;

upstream raw materials:

7-bromo-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one

4-benzyl-7-bromo-2,3,4,5-tetrahydro-1,4-benzoxazepine

1,1-dimethylethyl 7-bromo-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

5-bromosalicyclaldehyde

Downstream raw materials:

1,1-dimethylethyl 7-bromo-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

7-bromo-4-{5-[(4-fluorophenyl)methyl]-6-methylpyrimidin-4-yl}-2,3,4,5-tetrahydro-1,4-benzoxazepine

[7-(6-aminopyridin-3-yl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)-phenyl]methanone

7-bromo-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one